Evidence map›Paper›PMID 38681849›Full record

ArticleFrontiers in veterinary science2024

Assisting decision-making on age of neutering for German Short/Wirehaired Pointer, Mastiff, Newfoundland, Rhodesian Ridgeback, Siberian Husky: associated joint disorders, cancers, and urinary incontinence.

Lynette Arnason Hart, Abigail Paige Thigpen, Benjamin L Hart, Neil H Willits, Maya Lee, Miya M Babchuk, Jenna Lee, Megan Ho, Sara T Clarkson, Juliann W Chou

Abstract read
In one paragraph

Article in Frontiers in veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lynette Arnason HartSchool of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Abigail Paige ThigpenSchool of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Benjamin L HartSchool of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Neil H WillitsDepartment of Statistics, College of Letters and Science, University of California, Davis, Davis, CA, United States.
Maya LeeSchool of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Miya M BabchukSchool of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Jenna LeeSchool of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Megan HoSchool of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Sara T ClarksonSchool of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Juliann W ChouSchool of Veterinary Medicine, University of California, Davis, Davis, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spaying female and castrating male dogs, hereinafter referred to as neutering, is a US convention for the first year in the dog's life. Research on 35 breeds of dogs revealed that early neutering increases risks of joint disorders, such as hip dysplasia (HD), elbow dysplasia (ED), or cranial cruciate ligament (CCL) tear, or cancers, such as lymphosarcoma (LSA), mast cell tumor (MCT), hemangiosarcoma (has), or osteosarcoma (OSA), for some breeds. Joint disorder risks are heightened for some larger breeds and for mixed-breed dogs weighing more than 20 kg. Some breeds had elevated risks for cancers. Several other research teams have reported health complications associated with neutering. The study goal includes using the same methodology for data collection and analyses as in the study on 35 breeds for five additional dog breeds weighing at least 20 kg. The breeds were: German Short/Wirehaired Pointer, Mastiff, Newfoundland, Rhodesian Ridgeback, and Siberian Husky. Major differences among breeds appeared in vulnerability to joint disorders and cancers with early neutering: male and female Pointer breeds had elevated joint disorders and increased cancers; male Mastiff breeds had increased CCL and LSA and females had non-significant elevated CCL risks; female Newfoundland breeds had heightened risks for joint disorders and males had non-significant elevated risks; female Ridgeback breeds had heightened MCT with very early neutering; and Siberian Huskies showed no significant effects on joint disorders or cancers, but female breeds showed a non-significant but elevated CCL. Updated guidelines cover 40 dog breeds. These results further emphasize the importance of personalized decisions regarding the neutering of dogs, considering the dog's breed, sex, and context.

Indexed as

40 dog breedscranial cruciate ligament tearelbow dysplasiahemangiosarcomahip dysplasialymphosarcomamast cell tumorosteosarcoma

Identifiers

PMID38681849
PMCPMC11046931

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.