ReviewFrontiers in aging neuroscience2024
Cognitive reserve over the life course and risk of dementia: a systematic review and meta-analysis.
Review in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Comparative effectiveness of rhythmic grip training of various intensities on cognitive function in young adults: a fNIRS study.Frontiers in neuroscience · 2025Trial
- Low-Sample Input miRNA Profiling in Extracellular Vesicles-Enriched Plasma Fractions from Older Adults With/out Cognitive Impairment.International journal of molecular sciences · 2026Article
- Social engagement, formal education, and cognitive outcomes among older adults in India: A longitudinal population-based study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The social environment and cognitive aging over the life course: laying out critical concepts and research gaps.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Methodological Framework for the Design and Implementation of a US Latine-Hispanic Digital Brain Health Program: User-Centered Design Approach.JMIR formative research · 2026Article
- Three-Year Changes in Cognitive and Brain Functions Among Community-Dwelling Older Adults Who Continue Working.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Cross-cultural adaptation and psychometric evaluation of the Chinese version of the short version of the Cognitive Reserve Index Questionnaire (s-CRIq): a cross-sectional study.BMC psychiatry · 2026Article
- Cognitive Impairment, Dementia and Depression in Older Adults.Journal of clinical medicine · 2026Review
- Moderating effect of the domains of the cognitive reserve index questionnaire (CRIq) on longitudinal change slopes in episodic memory across the cognitive aging continuum.Scientific reports · 2026Article
- Prevalence of neurocognitive dysfunction and associated risk factors among follow-up diabetic type 2 patients in diabetes center of Al-Thawra hospital, SanaFrontiers in endocrinology · 2026Article
- Kinestesia: the prefrontal EEG response to a cognitive-motor intervention is graded by baseline cognitive status.Frontiers in aging neuroscience · 2026Article
- Artificial intelligence and machine learning for precision prevention of cognitive decline: integrating multimodal biomarkers, lifestyle interventions, and natural medicines from prediction to clinical practice.Frontiers in aging neuroscience · 2026Review
- Revitalizing old age: impact of a cognitive stimulation programme on emotional wellbeing and cognitive-executive functioning in older adults from Tacna, Peru.Frontiers in public health · 2026Article
- Diagnostic and treatment strategies in a memory clinic for older adults in a region with a predominantly low-income population.Frontiers in dementia · 2026Article
- A multilevel conceptual framework for dementia: from life-course mechanisms to public health strategies.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Review
- New Alzheimer's disease diagnostics and psychological clinical perspectives.Frontiers in psychology · 2026Article
- Association of MTHFR C677T and A1298C Polymorphisms in Metabolic Alterations, Neuroimaging, and Cognitive Decline in Alzheimer's Disease: Case-Control and Bioinformatics Insights.Molecular neurobiology · 2025Article
- Profiles of Aging Based on Cognition, Affect, and Brain Reserve.bioRxiv : the preprint server for biology · 2025Article
- Experiential factors mediate the link between brain status and theory of mind in building-up cognitive reserve.Scientific reports · 2025Article
- Association Between Shift Work and Auditory-Cognitive Processing in Middle-Aged Healthcare Workers.Audiology research · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The number of people with dementia is soaring. Cognitive reserve has been thought to be associated with dementia risk. It is not clear at which period in the life course and which cognitive reserve proxies contribute to the reduced risk of dementia. Methods: By scanning four databases (PubMed, Embase, Web of Science, and MEDLINE) up to Jun 3, 2023, longitudinal studies of life-course cognitive reserve and risk of dementia were found. The HRs and 95% CIs for each study were summarized using random effects models. Subgroup analyses and sensitivity analyses were conducted. Utilizing funnel plots, Begg and Egger tests, publication bias was investigated. Results: A total of 27 studies were included, containing 10 in early-life, 10 in middle-life, and 13 in late-life. All studies used validated questionnaires to measure cognitive reserve, and dementia diagnosis followed recognized worldwide guidelines. All included studies were of medium or low risk. Cognitive reserve in early-life (Hazard ratio (HR): 0.82; 95% confidence interval (CI): 0.79-0.86), middle-life (HR: 0.91; 95% CI: 0.84-0.98) and late-life (HR: 0.81; 95% CI: 0.75-0.88) all have protective effects on dementia risk. Multiple sensitivity analyses showed consistent results. Conclusion: Dementia risk is reduced by the buildup of cognitive reserves during life-course. Accumulation of proxies for cognitive reserve in early and late life had the greatest effect on dementia risk reduction. Social connection may be an effective approach to lower dementia risk.
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