Evidence map›Paper›PMID 38681192›Full record

ArticleFrontiers in pharmacology2024

Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment.

Kenneth R Gundle, Karthik Rajasekaran, Jeffrey Houlton, Gary B Deutsch, Thomas J Ow, Robert G Maki, John Pang, Cherie-Ann O Nathan, Daniel Clayburgh, Jason G Newman and 24 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Kenneth R GundleDepartment of Orthopaedics and Rehabilitation, Oregon Health and Science University, Portland, OR, United States.
Karthik RajasekaranDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, United States.
Jeffrey HoultonSarah Cannon Research Institute, Charleston, SC, United States.
Gary B DeutschZucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY, United States.
Thomas J OwDepartment of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States.
Robert G MakiZucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY, United States.
John PangDepartment of Otolaryngology/Head and Neck Surgery, Louisiana State University Health Shreveport, Shreveport, LA, United States.
Cherie-Ann O NathanDepartment of Otolaryngology/Head and Neck Surgery, Louisiana State University Health Shreveport, Shreveport, LA, United States.
Daniel ClayburghPortland Veterans Affairs Medical Center, Portland, OR, United States.
Jason G NewmanDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, United States.
Elyse BrinkmannDepartment of Orthopaedics and Sports Medicine, University of Washington School of Medicine, Seattle, WA, United States.
Michael J WagnerDivision of Oncology, University of Washington, Seattle, WA, United States.
Seth M PollackDivision of Oncology, University of Washington, Seattle, WA, United States.
Matthew J ThompsonDepartment of Orthopaedics and Sports Medicine, University of Washington School of Medicine, Seattle, WA, United States.
Ryan J LiDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, OR, United States.
Vikas MehtaDepartment of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States.
Bradley A SchiffDepartment of Otorhinolaryngology-Head and Neck Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States.
Barry I WenigDepartment of Otolaryngology-Head and Neck Surgery, University of Illinois at Chicago, Chicago, IL, United States.
Paul L SwiecickiDepartment of Hematology Oncology, University of Michigan Medical School, Ann Arbor, MI, United States.
Alice L TangDepartment of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Jessica L DavisDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.
Annemieke van ZanteDepartment of Pathology, University of California San Francisco, San Francisco, CA, United States.
Jessica A BertoutPresage Biosciences, Inc., Seattle, WA, United States.
Wendy JenkinsPresage Biosciences, Inc., Seattle, WA, United States.
Atticus TurnerPresage Biosciences, Inc., Seattle, WA, United States.
Marc GrenleyPresage Biosciences, Inc., Seattle, WA, United States.
Connor BurnsPresage Biosciences, Inc., Seattle, WA, United States.
Jason P FrazierPresage Biosciences, Inc., Seattle, WA, United States.
Angela MerrellPresage Biosciences, Inc., Seattle, WA, United States.
Kimberly H W SotteroPresage Biosciences, Inc., Seattle, WA, United States.
Jonathan M J DerryPresage Biosciences, Inc., Seattle, WA, United States.
Kate C GillespiePresage Biosciences, Inc., Seattle, WA, United States.
Bre MillsPresage Biosciences, Inc., Seattle, WA, United States.
Richard A KlinghofferPresage Biosciences, Inc., Seattle, WA, United States.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Arrayed drug microinjection for guiding precision medicine in relapsed lymphomaR44CA144104 · NCI · PRESAGE BIOSCIENCES, INC. · PI KLINGHOFFER, RICHARD · 2016 to 2018
$3.0M
Sideport Needle Array Technologies for Prioritizing Drugs for Cancer PatientsR42CA144104 · NCI · PRESAGE BIOSCIENCES, INC. · PI OLSON, JAMES M · 2010 to 2012
$1.4M
NCI NIH HHS P30 CA008748NCI NIH HHS R42 CA144104NCI NIH HHS R44 CA144104
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

drug developmentintratumoral microdosingmultidrug analysespharmacodynamicsphase 0spatial profilingtumor microenvironment

Identifiers

PMID38681192
PMCPMC11048044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.