Evidence map›Paper›PMID 38680941›Full record

ArticleBiological psychiatry global open science2024

Carbon Dioxide Reactivity Differentially Predicts Fear Expression After Extinction and Retrieval-Extinction in Rats.

Marissa Raskin, Nicole E Keller, Laura A Agee, Jason Shumake, Jasper A J Smits, Michael J Telch, Michael W Otto, Hongjoo J Lee, Marie-H Monfils

Abstract read
In one paragraph

Article in Biological psychiatry global open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. COAddiction biology · 2026
    Article
  2. Article
  3. Associations of COPhysiology & behavior · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marissa RaskinInstitute for Neuroscience, University of Texas at Austin, Austin, Texas.
Nicole E KellerInstitute for Neuroscience, University of Texas at Austin, Austin, Texas.
Laura A AgeeDepartment of Neuroscience, University of Texas at Austin, Austin, Texas.
Jason ShumakeDepartment of Psychology, University of Texas at Austin, Austin, Texas.
Jasper A J SmitsDepartment of Psychology, University of Texas at Austin, Austin, Texas.
Michael J TelchDepartment of Psychology, University of Texas at Austin, Austin, Texas.
Michael W OttoDepartment of Psychological & Brain Sciences, Boston University, Boston, Massachusetts.
Hongjoo J LeeInstitute for Neuroscience, University of Texas at Austin, Austin, Texas.
Marie-H MonfilsInstitute for Neuroscience, University of Texas at Austin, Austin, Texas.

Funding

1/2: CO2 Reactivity as a Biomarker of Non-response to Exposure-based TherapyR01MH125951 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI Marie H. Monfils, Jasper Smits · 2022 to 2026
$3.6M
2/2-CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based TherapyR01MH125949 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Michael W. Otto · 2022 to 2026
$2.8M
CO2 reactivity and orexin activation as predictors of extinction phenotype to fear and reward cuesF31AA030936 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI RASKIN, MARISSA RENEE · 2023 to 2024
$90k
NIAAA NIH HHS F31 AA030936NIMH NIH HHS R01 MH125949NIMH NIH HHS R01 MH125951
6 · The paper itself

Abstract

Background: Cues present during a traumatic event may result in persistent fear responses. These responses can be attenuated through extinction learning, a core component of exposure therapy. Exposure/extinction is effective for some people, but not all. We recently demonstrated that carbon dioxide (CO Methods: Male rats first underwent a CO Results: We found that retrieval-extinction resulted in lower freezing during extinction, LTM, and reinstatement than standard extinction. Using the best subset approach to linear regression, we found that CO Conclusions: CO

Indexed as

CO2ExtinctionFearIndividual differencesOrexinRetrieval-extinction

Identifiers

PMID38680941
PMCPMC11047292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.