Evidence map›Paper›PMID 38680665›Full record

ArticleiScience2024

Identification of eight genes associated with recurrent patellar dislocation.

Zijie Xu, Siyuan Huang, Yifan Song, Chao Xu, Hongyu Yan, Ouyang Linkun, Bo Lv, Fuzhen Yuan, Bingbing Xu, Haijun Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zijie XuSports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, China.
Siyuan HuangAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Yifan SongOrthopaedic Sports Medicine Center, Beijing Tsinghua Changgung Hospital, Affiliated Hospital of Tsinghua University, Beijing, China.
Chao XuThe Department of Joint Surgery and Sports Medicine, The Second Affiliated Hospital of Xinjiang Medical University, Urumchi, China.
Hongyu YanDepartment of Pediatric Neurology, Children's Hospital Affiliated to the Capital Institute of Pediatrics, Peking University, Beijing, China.
Ouyang LinkunAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Bo LvDepartment of Orthopedics, People's Hospital of Guilin, Guilin, Guangxi, China.
Fuzhen YuanSports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, China.
Bingbing XuSports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, China.
Haijun WangSports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, China.
Ruibin XiSchool of Mathematical Sciences and Center for Statistical Science, Peking University, Beijing, China.
Jia-Kuo YuOrthopaedic Sports Medicine Center, Beijing Tsinghua Changgung Hospital, Affiliated Hospital of Tsinghua University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inheritance of recurrent patellar dislocation (RPD) is known, but the susceptible gene remains unidentified. Here, we performed the first whole exome sequencing (WES) cohort study to identify the susceptible genes. The results showed eight genes were associated with this disease. Notably, the carboxypeptidase D (CPD) gene showed the highest relevance based on its gene function and tissue expression. Single-cell sequencing results indicate that the CPD gene is involved in the pathophysiological process of RPD through granulocytes. Implicated pathways include nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and Wnt/β-catenin signaling, potentially influencing CPD's role in RPD pathogenesis. This study identified the susceptible gene and investigates the potential pathogenesis of RPD, which provided a new prospect for the understanding of RPD. Besides, it would offer the theoretical basis for disease prevention and genetic counseling.

Indexed as

Clinical geneticsPathophysiologyTranscriptomics

Identifiers

PMID38680665
PMCPMC11046295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.