Evidence map›Paper›PMID 38680449›Full record

ArticleFrontiers in neuroscience2024

Retinal atrophy, inflammation, phagocytic and metabolic disruptions develop in the MerTK-cleavage-resistant mouse model.

Julie Enderlin, Quentin Rieu, Salomé Réty, Elora M Vanoni, Solène Roux, Julie Dégardin, Quénol César, Sébastien Augustin, Caroline Nous, Bishuang Cai and 3 more

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In one paragraph

Article in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Julie Enderlin *INSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.
Quentin Rieu *INSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.
Salomé RétyINSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.
Elora M VanoniINSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.
Solène RouxINSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.
Julie DégardinINSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.
Quénol CésarINSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.
Sébastien AugustinINSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.
Caroline NousINSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.
Bishuang CaiDivision of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Valérie FontaineINSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.
Florian SennlaubINSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.
Emeline F NandrotINSERM, CNRS, Institut de la Vision, Therapeutics Department, Sorbonne Université, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the eye, cells from the retinal pigment epithelium (RPE) facing the neurosensory retina exert several functions that are all crucial for long-term survival of photoreceptors (PRs) and vision. Among those, RPE cells phagocytose under a circadian rhythm photoreceptor outer segment (POS) tips that are constantly subjected to light rays and oxidative attacks. The MerTK tyrosine kinase receptor is a key element of this phagocytic machinery required for POS internalization. Recently, we showed that MerTK is subjected to the cleavage of its extracellular domain to finely control its function. In addition, monocytes in retinal blood vessels can migrate inside the inner retina and differentiate into macrophages expressing MerTK, but their role in this context has not been studied yet. We thus investigated the ocular phenotype of MerTK cleavage-resistant (MerTK

Indexed as

defective phagocytosisinflammationMerTKmetabolic dysfunctionretinal atrophyretinal pigment epitheliumsoluble receptor

Identifiers

PMID38680449
PMCPMC11047123

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.