Evidence map›Paper›PMID 38680390›Full record

ArticleConsortium psychiatricum2020

Schizophrenia and toxoplasmosis: association with catatonic symptoms.

Dmitry V Romanov, Aleksey Iu Brazhnikov, Denis S Andreyuk, Natalia V Zakharova, Lidia V Bravve, Vasilisa A Kovaleva, Evgeniya V Abbazova, Dmitriy B Goncharov, Irina V Titova, Elvira A Domonova and 1 more

Abstract read
In one paragraph

Article in Consortium psychiatricum, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dmitry V RomanovI.M. Sechenov First Moscow State Medical University (Sechenov University).ORCID https://orcid.org/0000-0002-1822-8973
Aleksey Iu BrazhnikovI.M. Sechenov First Moscow State Medical University (Sechenov University).ORCID https://orcid.org/0000-0002-5587-8860
Denis S AndreyukMental-health clinic No. 1 named after N.A. Aleхeev.ORCID https://orcid.org/0000-0002-3349-5391
Natalia V ZakharovaMental-health clinic No. 1 named after N.A. Aleхeev.ORCID https://orcid.org/0000-0001-7354-7216
Lidia V BravveMental-health clinic No. 1 named after N.A. Aleхeev.ORCID https://orcid.org/0000-0001-5380-4406
Vasilisa A KovalevaN.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia.ORCID https://orcid.org/0000-0003-0215-4938
Evgeniya V AbbazovaN.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia.ORCID https://orcid.org/0000-0001-6328-8142
Dmitriy B GoncharovN.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia.ORCID https://orcid.org/0000-0002-0250-4902
Irina V TitovaN.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia.
Elvira A DomonovaN.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russia.ORCID https://orcid.org/0000-0001-8262-3938
George P KostyukMental-health clinic No. 1 named after N.A. Aleхeev.ORCID https://orcid.org/0000-0003-4320-3644

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The association between schizophrenia and toxoplasmosis has been demonstrated in a number of studies: the prevalence of schizophrenia is significantly higher in toxoplasmosis positive subjects than in those with Objectives: To identify clinical phenomena that are typical for toxoplasmosis-associated ( Methods: A retrospective database analysis of serum samples from 105 inpatients with schizophrenia (ICD-10code: F20; including 55 male patients; mean age of 27.4 6.4 years) was carried out. The clinical examination involved a structured interview including ICD-10 and E. Bleulers criteria for schizophrenia and psychometric tests(Positive and Negative Scales of PANSS). Serum antibodies (IgG) to Results: The proportion of seropositive patients in the sample was 16.2%. Comparing schizophrenia patients, who were seropositive or seronegative for toxoplasmosis, there were no statistically significant differences for the mean total PANSS score, mean PANSS-P, PANSS-N or PANSS-G scores. For the majority of PANSS items, differences were also statistically insignificant, except for G5 and G6mannerism and posturing. Seropositive patients had a higher score for this item than seronegative patients: 3.5 versus 2.1 points (U=389.5; р=0.001). Depression, on the contrary,was less pronounced in seropositive than seronegative patients: 1.4 versus 2.4 points (U=509.5; р=0.023). In addition,in seropositive patients, the frequency of symptoms such as mutism according to ICD-10 criteria for schizophrenia was significantly higher (23.5% versus 3.4%, X Conclusion: The association between a positive toxoplasmosis status in patients with schizophrenia and catatonic symptoms has been revealed for the first time and should be verified in larger studies.

Indexed as

catatoniaPANSSPositive and Negative Syndrome ScaleschizophreniaT.gondiitoxoplasmosis

Identifiers

PMID38680390
PMCPMC11047268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.