Evidence map›Paper›PMID 38679978›Full record

ReviewAsian Pacific journal of cancer prevention : APJCP2024

Alteration in the Expression of Circular Rnas and its association with the Development and Progression of Osteosarcoma, an Integrative Review with High Sensitivity Research.

Felipe Alves De Lima, Fernando Liberalino Fernandes, Daria Raquel Queiroz De Almeida, Amanda Estevam Carvalho, Valéria Duarte Almeida, Gilson Aquino Cavalcante, Nickson Melo De Morais, Tayline Dantas Rodrigues, Ellany Gurgel Cosme Do Nascimento, Ivana Alice Teixeira Fonseca and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Felipe Alves De LimaDepartment of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
Fernando Liberalino FernandesDepartment of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.ORCID 0009-0009-9260-2255
Daria Raquel Queiroz De AlmeidaDepartment of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
Amanda Estevam CarvalhoDepartment of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
Valéria Duarte AlmeidaDepartment of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
Gilson Aquino CavalcanteDepartment of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
Nickson Melo De MoraisDepartment of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
Tayline Dantas RodriguesDepartment of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
Ellany Gurgel Cosme Do NascimentoDepartment of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
Ivana Alice Teixeira FonsecaDepartment of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.
Christiane Medeiros BezerraDepartment of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Brazil.
Jose Verissimo FernandesDepartment of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Brazil.
Thales Thales Allyrio Araujo De Medeiros FernandesDepartment of Biomedical Sciences, Rio Grande do Norte State University, Mossoró, Brazil.ORCID 0000-0003-4559-8918

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteosarcoma is the most common primary malignant bone tumor, mainly affecting children, young adults, and the elderly. It is an aggressive cancer with a poor prognosis, exhibiting low survival rates even with standard treatment. Recently, circular RNA molecules capable of influencing gene expression through various functions, with their main role being acting as microRNA sponges and reducing their intracellular expression, have been identified. Recent studies have linked circular RNAs to osteosarcoma development and progression. Therefore, the present study aimed to investigate the alteration in circular RNA expression during osteosarcoma development and progression.

methodsAn integrative literature review was conducted from September 10th to November 12th, 2021, using the following databases: PubMed/MEDLINE, SCOPUS, Web of Science, OVID, and EMBASE. 129 full articles were included in the review. The obtained data were organized using a standardized data collection instrument, which included the following information: altered expression profile of circular RNAs, associated cancer hallmarks, clinical-pathological relationships of circular RNAs, and perspectives on the studied circular RNAs.

resultsA total of 94 distinct circular RNAs were identified, predominantly showing an increased expression pattern. Approximately 91% of the studies that aimed to identify the mechanisms of action of circular RNAs highlighted the function of circular RNAs as microRNA sponges. The most associated cancer hallmarks with the identified circular RNAs were proliferative signaling induction, invasion and metastasis, and resistance to cell death. The altered expression of these circular RNAs generally correlated with a worse prognosis for patients, as evidenced by clinical features such as shorter survival, advanced Enneking and/or TNM stage, higher incidence of metastasis, larger tumor size, and increased chemoresistance. CONSLUSION: These findings indicate the significance of circular RNA molecules in osteosarcoma carcinogenesis, suggesting their potential as new prognostic and/or diagnostic biomarkers, as well as alternative therapeutic targets in the fight against osteosarcoma.

Indexed as

Bone NeoplasmsDisease ProgressionOsteosarcomaRNA, CircularBiomarkers, TumorGene Expression Regulation, NeoplasticHumansMicroRNAsPrognosisBiomarkers, TumorMicroRNAsRNA, CircularCircular RNAOncogenesisosteosarcoma

Identifiers

PMID38679978
PMCPMC11162731

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.