Evidence map›Paper›PMID 38679882›Full record

ArticleACS synthetic biology2024

Engineered Biosynthesis and Anticancer Studies of Ring-Expanded Antimycin-Type Depsipeptides.

Zhijuan Hu, Di Gu, Will Skyrud, Yongle Du, Rui Zhai, Juan Wang, Wenjun Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhijuan HuDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0009-0004-0571-0498
Di GuDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0003-4860-7701
Will SkyrudDepartment of Chemistry, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-2094-5314
Yongle DuDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0002-5727-3355
Rui ZhaiDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0001-5032-9689
Juan WangDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.
Wenjun ZhangDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.ORCID 0000-0001-9348-972X

Funding

Biosynthesis of unusual bio-orthogonal functionalities in natural productsR01GM136758 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZHANG, WENJUN · 2020 to 2023
$1.5M
Biosynthesis of Unusual Bio-Orthogonal Functionalities in Natural ProductsR35GM153289 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Wenjun Zhang · 2024 to 2026
$1.1M
NIGMS NIH HHS R01 GM136758NIGMS NIH HHS R35 GM153289
6 · The paper itself

Abstract

Respirantins are 18-membered antimycin-type depsipeptides produced by

Indexed as

Antimycin AAntineoplastic AgentsDepsipeptidesMultigene FamilyStreptomycesBiosynthetic PathwaysHeLa CellsHumansMCF-7 CellsPolyketide SynthasesStructure-Activity RelationshipantimycinAntimycin AAntineoplastic AgentsDepsipeptidesPolyketide Synthasesanticancer activitybiosynthesisbiphasic dose–responsePKS engineeringrespirantin

Identifiers

PMID38679882
PMCPMC11483242

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.