ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2024
Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Analytic Bounds on GAMLSS Model Variability of Normative White Matter Brain Charts.bioRxiv : the preprint server for biology · 2026Article
- Analytic Bounds on GAMLSS Model Variability of Normative White Matter Brain Charts.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Frontal Cortex Entropy Derived From Resting-State fNIRS for Brain Age Prediction in Major Depressive Disorder.Depression and anxiety · 2026Article
- Disentangling Neurodegeneration with Brain Age Gap Prediction Models: A Graph Signal Processing Perspective.ArXiv · 2025Article
- Stem-cell-derived extracellular vesicles in neurodegeneration and neuroaging: therapeutic potential and challenges.Extracellular vesicles and circulating nucleic acids · 2025Review
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Authors and funding
20 authors.
Funding
Abstract
backgroundPatients with major depressive disorder (MDD) can present with altered brain structure and deficits in cognitive function similar to those seen in aging. However, the interaction between age-related brain changes and brain development in MDD remains understudied. In a cohort of adolescents and adults with and without MDD, we assessed brain aging differences and associations through a newly developed tool that quantifies normative neurodevelopmental trajectories.
methodsA total of 304 participants with MDD and 236 control participants without depression were recruited and scanned from 3 studies under the Canadian Biomarker Integration Network for Depression. Volumetric data were used to generate brain centile scores, which were examined for 1) differences between participants with MDD and control participants; 2) differences between individuals with versus without severe childhood maltreatment; and 3) correlations with depressive symptom severity, neurocognitive assessment domains, and escitalopram treatment response.
resultsBrain centiles were significantly lower in the MDD group than in the control group. Brain centile was also significantly correlated with working memory in the control group but not the MDD group. No significant associations were observed between depression severity or antidepressant treatment response and brain centiles. Likewise, childhood maltreatment history did not significantly affect brain centiles.
conclusionsConsistent with previous work on machine learning models that predict brain age, brain centile scores differed in people diagnosed with MDD, and MDD was associated with differential relationships between centile scores and working memory. The results support the notion of atypical development and aging in MDD, with implications for neurocognitive deficits associated with aging-related cognitive function.
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