Evidence map›Paper›PMID 38678489›Full record

ArticleBulletin of mathematical biology2024

Modelling the Impact of NETosis During the Initial Stage of Systemic Lupus Erythematosus.

Vladimira Suvandjieva, Ivanka Tsacheva, Marlene Santos, Georgios Kararigas, Peter Rashkov

Abstract read
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In one paragraph

Article in Bulletin of mathematical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vladimira SuvandjievaInstitute of Mathematics and Informatics, Bulgarian Academy of Sciences, ul. Akad. Georgi Bonchev, blok 8, 1113, Sofia, Bulgaria.
Ivanka TsachevaFaculty of Biology, Sofia University "Sveti Kliment Ohridski", bul. Dragan Tsankov 8, 1164, Sofia, Bulgaria.
Marlene SantosLAQV/REQUIMTE, Escola Superior de Saúde, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida, 400, 4200-072, Porto, Portugal.
Georgios KararigasDepartment of Physiology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101, Reykjavik, Iceland.
Peter RashkovInstitute of Mathematics and Informatics, Bulgarian Academy of Sciences, ul. Akad. Georgi Bonchev, blok 8, 1113, Sofia, Bulgaria. p.rashkov@math.bas.bg.ORCID http://orcid.org/0000-0003-4093-7837

Funding

Bulgarian National Science Fund KP-06-KOST/13European Cooperation in Science and Technology CA21147
6 · The paper itself

Abstract

The development of autoimmune diseases often takes years before clinical symptoms become detectable. We propose a mathematical model for the immune response during the initial stage of Systemic Lupus Erythematosus which models the process of aberrant apoptosis and activation of macrophages and neutrophils. NETosis is a type of cell death characterised by the release of neutrophil extracellular traps, or NETs, containing material from the neutrophil's nucleus, in response to a pathogenic stimulus. This process is hypothesised to contribute to the development of autoimmunogenicity in SLE. The aim of this work is to study how NETosis contributes to the establishment of persistent autoantigen production by analysing the steady states and the asymptotic dynamics of the model by numerical experiment.

Indexed as

ApoptosisExtracellular TrapsLupus Erythematosus, SystemicMathematical ConceptsModels, ImmunologicalNeutrophilsAutoantigensComputer SimulationHumansMacrophage ActivationMacrophagesNeutrophil ActivationAutoantigensAntigen presentationBifurcation analysisImmune responseLupus

Identifiers

PMID38678489
PMCPMC11056343

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.