ArticleScientific reports2024
Oral microbial signatures associated with age and frailty in Canadian adults.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- From culture-based to 16S sequencing approaches: oral microbiota changes in aging, frailty, and oral hypofunction - a systematic review.BMC oral health · 2026Pooled it
- Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects.iMeta · 2026Review
- Baseline Oral Microbiota Richness Is Associated with Training-Induced Improvements in Relative Handgrip Strength in Older Adults.Nutrients · 2026Article
- [Research Advances on the Role of the Oral Microbiota in Age-Related Homeostatic Dysregulation and Systemic Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Population-based characterisation of child and adolescent oral bacterial microbiomes.Microbiome · 2026Article
- A cross-sectional study of supragingival microbiome depending on age in Korean population.Scientific reports · 2026Article
- Masticatory function and frailty: insights from NHANES and CHARLS.BMC public health · 2026Article
- Oral microbiome signatures predict biological age and host health.Nature communications · 2026Article
- Oral microbiome diversity shapes the association between leisure-time physical activity and cognitive function among older adults.iScience · 2026Article
- From mouth to muscle: mechanistic and interventional perspectives on the tongue-coating microbiome in sarcopenia.Journal of translational medicine · 2026Review
- Advances in multi-omics and aging clock research for female reproductive health and aging.MedScience · 2026Review
- Article
- Oral short-chain fatty acid-producing bacteria may be associated with biological age and cognition among the oldest old.Communications medicine · 2025Article
- Diet-microbiome synergy: unraveling the combined impact on frailty through interactions and mediation.Nutrition journal · 2025Article
- Key Bacterial Taxa Differences Associated with Polypharmacy in Elderly Patients.Microorganisms · 2025Article
- Chronological age estimation from human microbiomes with transformer-based Robust Principal Component Analysis.Communications biology · 2025Article
- Chewing Matters: Masticatory Function, Oral Microbiota, and Gut Health in the Nutritional Management of Aging.Nutrients · 2025Review
- Characterizing biomarkers of ageing in Singaporeans: the ABIOS observational study protocol.GeroScience · 2025Article
- The oral microbiome in aging: a window into health and longevity.Journal of oral microbiology · 2025Review
- Oral Mycobiome Alterations in Postmenopausal Women: Links to Inflammation, Xerostomia, and Systemic Health.Biomedicines · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to assess the association between the oral microbiome, age, and frailty. Data and saliva samples were obtained from male and female participants aged 35-70 years (n = 1357). Saliva samples were analysed by 16S rRNA gene sequencing and differences in microbial diversity and community compositions were examined in relation to chronological age and the frailty index (FI). Most alpha diversity measures (Richness, Shannon Diversity, Faith's Phylogenetic Diversity) showed an inverse association with frailty, whereas a positive association was observed with age and Shannon Diversity and Evenness. A further sex-stratified analysis revealed differences in measures of microbial diversity and composition. Multiple genera were detected as significantly differentially abundant with increasing frailty and age by at least two methods. With age, the relative abundance of Veillonella was reduced in both males and females, whereas increases in Corynebacterium appeared specific to males and Aggregatibacter, Fusobacterium, Neisseria, Stomatobaculum, and Porphyromonas specific to females. Beta diversity was significantly associated with multiple mental health components of the FI. This study shows age and frailty are differentially associated with measures of microbial diversity and composition, suggesting the oral microbiome may be a useful indicator of increased risk of frailty or a potential target for improving health in ageing adults.
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Registered trials
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