Evidence map›Paper›PMID 38677638›Full record

ArticleAmerican journal of ophthalmology2024

Alterations of the Ganglion Cell Complex in Age-Related Macular Degeneration: An Amish Eye Study Analysis.

Swetha Bindu Velaga, Ahmed Roshdy Alagorie, Mehdi Emamverdi, Maryam Ashrafkhorasani, Abbas Habibi, Muneeswar Gupta Nittala, Gagan Sing, Jonathan Haines, Margaret A Pericak-Vance, Dwight Stambolian and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Swetha Bindu VelagaFrom the Doheny Eye Institute (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., G.S., S.R.S.), University of California-Los Angeles, Los Angeles, California, USA; Department of Ophthalmology (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., S.R.S.), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Ahmed Roshdy AlagorieFrom the Doheny Eye Institute (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., G.S., S.R.S.), University of California-Los Angeles, Los Angeles, California, USA; Department of Ophthalmology (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., S.R.S.), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Ophthalmology (A.R.A.), Faculty of Medicine, Tanta University, Tanta, Egypt.
Mehdi EmamverdiFrom the Doheny Eye Institute (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., G.S., S.R.S.), University of California-Los Angeles, Los Angeles, California, USA; Department of Ophthalmology (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., S.R.S.), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Maryam AshrafkhorasaniFrom the Doheny Eye Institute (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., G.S., S.R.S.), University of California-Los Angeles, Los Angeles, California, USA; Department of Ophthalmology (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., S.R.S.), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Abbas HabibiFrom the Doheny Eye Institute (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., G.S., S.R.S.), University of California-Los Angeles, Los Angeles, California, USA; Department of Ophthalmology (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., S.R.S.), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Muneeswar Gupta NittalaFrom the Doheny Eye Institute (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., G.S., S.R.S.), University of California-Los Angeles, Los Angeles, California, USA; Department of Ophthalmology (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., S.R.S.), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Gagan SingFrom the Doheny Eye Institute (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., G.S., S.R.S.), University of California-Los Angeles, Los Angeles, California, USA; Department of Ophthalmology (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., S.R.S.), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jonathan HainesDepartment of Population & Quantitative Health Sciences (J.H.), Case Western Reserve University, Cleveland, Ohio, USA; Institute for Computational Biology (J.H.), Case Western Reserve University, Cleveland, Ohio, USA.
Margaret A Pericak-VanceJohn P. Hussman Institute for Human Genomics (M.A.P.-V), University of Miami Miller School of Medicine, Miami, Florida, USA.
Dwight StambolianDepartment of Ophthalmology (D.S.), University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Srinivas R SaddaFrom the Doheny Eye Institute (S.B.V., A.R.A., M.E., M.A., A.H., M.G.N., G.S., S.R.S.), University of California-Los Angeles, Los Angeles, California, USA. Electronic address: SSadda@doheny.org.
University of California, Los Angeles · USCase Western Reserve University · USUniversity of Miami · USUniversity of Pennsylvania · US

Funding

Genetic Epidemiology of Age-Related Macular Degeneration in the Older Order AmishR01EY023164 · NEI · UNIVERSITY OF PENNSYLVANIA · PI PERICAK-VANCE, MARGARET A., STAMBOLIAN, DWIGHT EDWARD · 2013 to 2017
$6.2M
Epidemiology of Biomarkers of AMD ProgressionR01EY030614 · NEI · DOHENY EYE INSTITUTE · PI Jonathan L Haines, Margaret A. Pericak-Vance · 2021 to 2026
$3.0M
NEI NIH HHS R01 EY023164NEI NIH HHS R01 EY030614
6 · The paper itself

Abstract

purposeTo compare the ganglion cell complex (GCC) thickness in eyes with age-related macular degeneration (AMD) vs healthy controls in an elderly Amish population.

designProspective cross-sectional study.

methodsThis is a post hoc analysis of the family-based prospective study of Amish subjects. Study subjects underwent imaging with the Cirrus HD-OCT (Carl Zeiss Meditec Inc) using a macular cube protocol of 512 × 128 scans (128 horizontal B-scans, each comprising 512 A-scans) over a 6 mm × 6 mm region centered on the fovea. The ganglion cell analysis algorithm calculated the GCC thickness by segmenting the outer boundaries of the retinal nerve fiber layer (RNFL) and inner plexiform layer (IPL) in all B-scans of the volume, with the region between these boundaries representing the combined thickness of the ganglion cell layer (GCL) and the IPL. A number of parameters were used to evaluate the GCC thickness: the average GCC thickness, minimum (lowest GCC thickness at a single meridian crossing the elliptical annulus), and sectoral (within each of 6 sectoral areas: superior, superotemporal, superonasal, inferior, inferonasal, and inferotemporal). The stage of AMD was graded on color fundus photographs in accordance with the Beckman Initiative for Macular Research classification system.

resultsOf 1339 subjects enrolled in the Amish eye study, a total of 1294 eyes of 1294 subjects had all required imaging studies of sufficient quality and were included in the final analysis. Of these, 798 (62%) were female. Following age adjustment, the average GCC thickness was significantly (P < .001) thinner in AMD subjects (73.71 ± SD; 13.77 µm) compared to normals (77.97 ± 10.42 µm). An independent t test showed that the early AMD (75.03 ± 12.45 µm) and late AMD (61.64 ± 21.18 µm) groups (among which eyes with geographic atrophy [GA] had the lowest thickness, of 58.10 ± 20.27 µm) had a statistically significant lower GCC thickness compared to eyes without AMD. There was no significant differences in average GCC thickness between early AMD and intermediate AMD (76.36 ± 9.25 µm) eyes.

conclusionsThe GCC thickness in AMD eyes is reduced compared to normal eyes; however, the relationship is complex, with the greatest reduction in late AMD eyes (particularly eyes with GA) but no difference between early and intermediate AMD eyes.

Indexed as

Nerve FibersRetinal Ganglion CellsTomography, Optical CoherenceAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMacular DegenerationMaleMiddle AgedProspective StudiesVisual Acuity

Identifiers

PMID38677638
PMCPMC13360661
OpenAlexW3181504473

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.