ArticleThe American journal of clinical nutrition2024
Associations of Lifestyle and Genetic Risks with Obesity and Related Chronic Diseases in the UK Biobank: A Prospective Cohort Study.
Article in The American journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Exploring the Role of Resistance Training in the Prevention and Management of Chronic Conditions: A Narrative Review.Clinics and practice · 2026Review
- Genetic and environmental influences on educational disparities in adult weight change: an individual-based pooled analysis of 11 twin cohorts.International journal of obesity (2005) · 2026Article
- Lifestyle and Dietary Behaviors Are Associated with Body Mass Index in Romanian Young Adults.Nutrients · 2026Article
- Mitochondrial signatures of infant mesenchymal stem cells predict child adiposity: The Healthy Start Study.Research square · 2026Article
- Review
- Article
- Targeting obesity and lipid metabolism profiles to prevent perianal abscesses: A case-control study and Mendelian randomization analysis.World journal of gastrointestinal surgery · 2026Article
- Dropout in supervised small-group exercise programs: a 7-year retrospective cohort study.Frontiers in public health · 2026Article
- Plasma inflammatory proteome profiles identify MASLD among children with overweight or obesity.Cardiovascular diabetology · 2025Article
- Self-selected vs. prescribed aerobic exercise intensity: impacts on pleasure in women with obesity.Frontiers in psychology · 2025Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInterplay between lifestyle risk scores (LRSs) and genetic risk scores (GRSs) on obesity and related chronic diseases are underinvestigated and necessary for understanding obesity causes and developing prevention strategies.
objectivesThis study aimed to investigate independent and joint associations and interactions of LRS and GRS with obesity prevalence and risks of diabetes, cardiovascular disease (CVD), and obesity-related cancer.
methodsIn this cohort study of 444,957 UK Biobank participants [age: 56.5 ± 8.1 y; BMI (in kg/m
resultsThe LRS and GRS were independently positively associated with all outcomes. Additive interactions of LRS and GRS were observed for all outcomes (P < 0.021). Comparing the top with bottom LRS quintile, prevalence differences (95% CIs) for obesity were 17.8% (15.9%, 19.7%) in the top GRS quintile and 10.7% (8.3%, 13.1%) in the bottom GRS quintile; for diabetes, CVD, and obesity-related cancer, incidence rate differences associated with per SD increase in LRS were greater in the top than that in the bottom GRS quintile. Participants from top quintiles of both LRS and GRS had 6.16-fold, 3.81-fold, 1.56-fold, and 1.44-fold higher odds/risks of obesity, diabetes, CVD, and obesity-related cancer, respectively, than those from bottom quintiles of both scores.
conclusionsHigher LRS was associated with higher obesity prevalence and risks of related chronic diseases regardless of GRS, highlighting the broad benefits of healthy lifestyles. Additive gene-lifestyle interactions emphasize the public health importance of lifestyle interventions among people with high genetic risks.
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