Hypothermia as potential therapeutic approach to attenuating soman-induced seizure, neuropathology, and mortality with an adenosine A

Crystal Munoz, Cindy Acon-Chen, Zora-Maya Keith, Tsung-Ming Shih

Open access · greenAbstract read

In one paragraph

Article in Neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

4.2field-weighted citation impact, top 7% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

Pharmacology of Adenosine ANeurotoxicity research · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Crystal MunozNeuroscience Department, Medical Toxicology Research Division, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, 21010-5400, USA.

Cindy Acon-ChenNeuroscience Department, Medical Toxicology Research Division, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, 21010-5400, USA.

Zora-Maya KeithNeuroscience Department, Medical Toxicology Research Division, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, 21010-5400, USA.

Tsung-Ming ShihNeuroscience Department, Medical Toxicology Research Division, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, 21010-5400, USA. Electronic address: tsungming.a.shih.civ@health.mil.

DEVCOM Army Research Laboratory · USU.S. Army Center for Health Promotion and Preventive Medicine · US

Funding

Acquisition of A MALDI-TOF Mass SpectrometerS10OD018013 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEARY, JULIE ANN · 2014 to 2014

$538k

NIH HHS AOD18013-001

6 · The paper itself

Abstract

Organophosphorus nerve agents, such as soman (GD), produce excitotoxic effects resulting in sustained status epilepticus (SSE) and brain damage. Previous work shows that neuronal inhibitory effects of A

Indexed as

Adenosine A1 Receptor AgonistsHypothermia, InducedRats, Sprague-DawleySeizuresSomanAdenosineAnimalsBody TemperatureBrainDisease Models, AnimalElectroencephalographyMaleRatsAdenosineAdenosine A1 Receptor AgonistsSomanAdenosine A(1) receptor agonistNeuroprotectionSeizure activitySomanTherapeutic hypothermia

Identifiers

PMID38677446

DOI10.1016/j.neuropharm.2024.109966

PMCPMC11197881

OpenAlexW4395673694

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.