Evidence map›Paper›PMID 38676925›Full record

ArticleCell reports2024

Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice.

Gabriele Chelini, Hadi Mirzapourdelavar, Peter Durning, David Baidoe-Ansah, Manveen K Sethi, Sinead M O'Donovan, Torsten Klengel, Luigi Balasco, Cristina Berciu, Anne Boyer-Boiteau and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. [Research Progress on the Mechanisms of Visual Cortical Plasticity].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Gabriele CheliniTranslational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA; Center for Mind/Brain Sciences, University of Trento, Rovereto 38068 Trento, Italy.
Hadi MirzapourdelavarMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases, Magdeburg 39120 Saxony-Anhalt, Germany.
Peter DurningTranslational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA.
David Baidoe-AnsahMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases, Magdeburg 39120 Saxony-Anhalt, Germany.
Manveen K SethiCenter for Biomedical Mass Spectrometry, Department of Biochemistry and Cell Biology, Boston University School of Medicine, Boston, MA 02118, USA.
Sinead M O'DonovanCognitive Disorders Research Laboratory, University of Toledo, Toledo, OH 43606, USA.
Torsten KlengelDepartment of Psychiatry, Harvard Medical School, Boston, MA 02215, USA; Translational Molecular Genomics Laboratory, Mclean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, University Medical Center Göttingen, 37075 Göttingen, Germany.
Luigi BalascoCenter for Mind/Brain Sciences, University of Trento, Rovereto 38068 Trento, Italy.
Cristina BerciuTranslational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA.
Anne Boyer-BoiteauTranslational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA.
Robert McCullumsmithCognitive Disorders Research Laboratory, University of Toledo, Toledo, OH 43606, USA.
Kerry J ResslerDepartment of Psychiatry, Harvard Medical School, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02215, USA; Neurobiology of Fear Laboratory, McLean Hospital, Belmont, MA 02478, USA.
Joseph ZaiaCenter for Biomedical Mass Spectrometry, Department of Biochemistry and Cell Biology, Boston University School of Medicine, Boston, MA 02118, USA; Bioinformatics Program, Boston University, Boston, MA 02215, USA.
Yuri BozziCenter for Mind/Brain Sciences, University of Trento, Rovereto 38068 Trento, Italy; CNR Neuroscience Institute Pisa, 56124 Pisa, Italy.
Alexander DityatevMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases, Magdeburg 39120 Saxony-Anhalt, Germany; Medical Faculty, Otto von Guericke University, Magdeburg 39106 Saxony-Anhalt, Germany; Center for Behavioral Brain Sciences, Otto von Guericke University, Magdeburg 39106 Saxony-Anhalt, Germany.
Sabina BerrettaTranslational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02215, USA. Electronic address: s.berretta@mclean.harvard.edu.
Harvard University · USGerman Center for Neurodegenerative Diseases · DEMcLean Hospital · USBoston University · USUniversity of Toledo · USUniversity of Trento · IT

Funding

SPARED CenterP50MH115874 · NIMH · MCLEAN HOSPITAL · PI RESSLER, KERRY J. · 2019 to 2023
$13.7M
Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala PathwaysR01MH108665 · NIMH · MCLEAN HOSPITAL · PI BOLSHAKOV, VADIM, RESSLER, KERRY J. · 2016 to 2025
$7.5M
Dysregulation of Appetitive & Aversive Amygdala Circuits in Bipolar DisorderR01MH120991 · NIMH · MCLEAN HOSPITAL · PI BERRETTA, SABINA, MCCARROLL, STEVEN ANDREW · 2020 to 2024
$4.0M
Translational assessment of brain bioenergetic function in schizophreniaR01MH121102 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI MARANO, CHRISTOPHER, MCCULLUMSMITH, ROBERT E · 2020 to 2024
$3.7M
Understanding the transgenerational epigenetic effect of maternal psychosocial trauma exposure on infants via lncRNA-sequencingR01HD102974 · NICHD · MCLEAN HOSPITAL · PI KLENGEL, TORSTEN, KOEN , NASTASSJA · 2020 to 2024
$2.9M
Role of the Extracellular Matrix in the Pathophysiology of Alzheimer's disorder: Regulation by OTX2R01MH104488 · NIMH · MCLEAN HOSPITAL · PI BERRETTA, SABINA, WOO, TSUNG-UNG W. · 2015 to 2019
$2.8M
Methods for measuring matrisome molecule similarity during disease processesR35GM144090 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JOSEPH ZAIA · 2022 to 2026
$2.1M
Cell-specific analysis of sub-kinomes in schizophreniaR01MH107487 · NIMH · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI MCCULLUMSMITH, ROBERT E, MELLER, JAREK · 2016 to 2020
$1.9M
A Thermo-Fisher Scientific Q-Exactive HF Mass Spectrometry SystemS10OD021651 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZAIA, JOSEPH · 2016 to 2016
$580k
Longitudinal DNA methylation in a non-human primate model of early-life stressR21HD088931 · NICHD · MCLEAN HOSPITAL · PI KLENGEL, TORSTEN, RESSLER, KERRY J. · 2017 to 2018
$473k
Effects of Stress and Obesity on Longitudinal Epigenetic ProgrammingR21HD097524 · NICHD · MCLEAN HOSPITAL · PI ETHUN, KELLY F, KLENGEL, TORSTEN · 2019 to 2020
$465k
A role for circular RNAs in schizophreniaR21MH117609 · NIMH · MCLEAN HOSPITAL · PI BERRETTA, SABINA, KLENGEL, TORSTEN · 2019 to 2020
$451k
NICHD NIH HHS R01 HD102974NICHD NIH HHS R21 HD088931NICHD NIH HHS R21 HD097524NIGMS NIH HHS R35 GM144090NIH HHS S10 OD021651NIMH NIH HHS P50 MH115874NIMH NIH HHS R01 MH104488NIMH NIH HHS R01 MH107487NIMH NIH HHS R01 MH108665NIMH NIH HHS R01 MH120991NIMH NIH HHS R01 MH121102NIMH NIH HHS R21 MH117609
6 · The paper itself

Abstract

Recent findings show that effective integration of novel information in the brain requires coordinated processes of homo- and heterosynaptic plasticity. In this work, we hypothesize that activity-dependent remodeling of the peri-synaptic extracellular matrix (ECM) contributes to these processes. We show that clusters of the peri-synaptic ECM, recognized by CS56 antibody, emerge in response to sensory stimuli, showing temporal and spatial coincidence with dendritic spine plasticity. Using CS56 co-immunoprecipitation of synaptosomal proteins, we identify several molecules involved in Ca

Indexed as

Extracellular MatrixLong-Term PotentiationMemoryNeuronal PlasticityAnimalsCA1 Region, HippocampalHippocampusMaleMiceMice, Inbred C57BLSynapseschondrotin sulfate proteoglycansCP: Cell biologyCP: NeuroscienceCS clustersextracellular matrixhippocampusimmunoprecipitationlearning and memorysensory manipulationsynaptic plasticityversican

Identifiers

PMID38676925
PMCPMC11251421
OpenAlexW4395681560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.