Evidence map›Paper›PMID 38676898›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

A Dynamic Sheep Model to Induce Pulmonary Hypertension and Right Ventricular Failure.

Carl A Johnson, Michael Cortelli, Gabriella Glomp, Courtney Cagnolatti, Caitlin T Demarest, Rei Ukita, Matthew Bacchetta

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
8.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Animal models of chronic thromboembolic pulmonary hypertension.Animal models and experimental medicine · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carl A JohnsonDepartment of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael CortelliDepartment of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Gabriella GlompVanderbilt University, Nashville, TN, USA.
Courtney CagnolattiVanderbilt University, Nashville, TN, USA.
Caitlin T DemarestDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Rei UkitaDepartment of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Matthew BacchettaDepartment of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. matthew.bacchetta@vumc.org.
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

The Road to Destination Therapy: Optimizing Long-Term Mechanical Cardiopulmonary Support for Pulmonary HypertensionR01HL140231 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BACCHETTA, MATTHEW DOMINIC · 2018 to 2021
$2.7M
The Road to Destination Therapy: Developing a Durable Ambulatory Mechanical Cardiopulmonary Support for Pulmonary HypertensionR01HL171577 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Matthew Dominic Bacchetta · 2024 to 2026
$2.2M
NHLBI NIH HHS R01 HL140231NHLBI NIH HHS R01 HL171577
6 · The paper itself

Abstract

Decompensated right ventricular failure (RVF) in pulmonary hypertension (PH) is fatal, with limited medical treatment options. Developing and testing novel therapeutics for PH requires a clinically relevant large animal model of increased pulmonary vascular resistance and RVF. This manuscript describes the method to induce an ovine PH-RVF model that utilizes left pulmonary artery (LPA) ligation, progressive main pulmonary artery (MPA) banding, and insertion of an RV pressure line for monitoring. The PA cuff and RV pressure tubing are connected to subcutaneous access ports. This model of PH-RVF is a versatile platform to control not only the disease severity, but also the RV's phenotypic response. Subjects undergo progressive PA band adjustments twice per week for approximately 9 weeks with sequential measures of RV pressure, PA cuff pressures, and mixed venous blood gas (SvO

Indexed as

Disease Models, AnimalHeart FailureHypertension, PulmonaryVentricular Dysfunction, RightAnimalsEchocardiographyHemodynamicsPulmonary ArterySheepAdult sheepExerciseExtracorporeal life supportPulmonary artery bandingPulmonary hypertensionRight ventricular failure

Identifiers

PMID38676898
OpenAlexW4395698929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.