Evidence map›Paper›PMID 38676857›Full record

ArticleBiotechnology letters2024

Facile engineering of aptamer-coupled silk fibroin encapsulated myogenic gold nanocomposites: investigation of antiproliferative activity and apoptosis induction.

Poorni Kaliyappan Elayappan, Kavitha Kandasamy, Vadivukkarasi Sasikumar, Muruganantham Bharathi, Abdurahman Hajinur Hirad, Abdullah A Alarfaj, Palanisamy Arulselvan, Ravindran Jaganathan, Rajeswari Ravindran, Jagadeesh Suriyaprakash and 1 more

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Article in Biotechnology letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Poorni Kaliyappan ElayappanDepartment of Biochemistry, Vivekanandha College of Arts and Sciences for Women (Autonomous), Elayampalayam, Tiruchengode, Namakkal, Tamil Nadu, 637205, India.
Kavitha KandasamyDepartment of Biochemistry, Vivekanandha College of Arts and Sciences for Women (Autonomous), Elayampalayam, Tiruchengode, Namakkal, Tamil Nadu, 637205, India.
Vadivukkarasi SasikumarDepartment of Biochemistry, K.S.Rangasamy College of Arts and Science, Tiruchengode, Namakkal, Tamil Nadu, 637215, India.
Muruganantham BharathiCenter for Bioinformatics, Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India.
Abdurahman Hajinur HiradDepartment of Botany and Microbiology, College of Science, King Saud University, P. O. Box. 2455, 11451, Riyadh, Saudi Arabia.
Abdullah A AlarfajDepartment of Botany and Microbiology, College of Science, King Saud University, P. O. Box. 2455, 11451, Riyadh, Saudi Arabia.
Palanisamy ArulselvanDepartment of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, 602 105, India.
Ravindran JaganathanPreclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak (UniKL-RCMP), 30450, Ipoh, Perak, Malaysia.
Rajeswari RavindranPreclinical Department, Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak (UniKL-RCMP), 30450, Ipoh, Perak, Malaysia.
Jagadeesh SuriyaprakashGuangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China.
Indumathi ThangaveluDepartment of Chemistry, CHRIST (Deemed to Be University), Bangalore, 560029, India. indumathi.t@christuniversity.in.ORCID http://orcid.org/0000-0001-5628-0441
King Saud University · SASwami Vivekanand College of Pharmacy · INUniversity of Kuala Lumpur · MYChrist University · INKarpagam Academy of Higher Education · INSaveetha University · INSouth China Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanocomposites selectively induce cancer cell death, holding potential for precise liver cancer treatment breakthroughs. This study assessed the cytotoxicity of gold nanocomposites (Au NCs) enclosed within silk fibroin (SF), aptamer (Ap), and the myogenic Talaromyces purpureogenus (TP) against a human liver cancer cell (HepG2). The ultimate product, Ap-SF-TP@Au NCs, results from a three-step process. This process involves the myogenic synthesis of TP@Au NCs derived from TP mycelial extract, encapsulation of SF on TP@Au NCs (SF-TP@Au NCs), and the conjugation of Ap within SF-TP@Au NCs. The synthesized NCs are analyzed by various characteristic techniques. Ap-SF-TP@Au NCs induced potential cell death in HepG2 cells but exhibited no cytotoxicity in non-cancerous cells (NIH3T3). The morphological changes in cells were examined through various biochemical staining methods. Thus, Ap-SF-TP@Au NCs emerge as a promising nanocomposite for treating diverse cancer cells.

Indexed as

Antineoplastic AgentsApoptosisAptamers, NucleotideCell ProliferationFibroinsGoldNanocompositesAnimalsHep G2 CellsHumansMetal NanoparticlesMiceNIH 3T3 CellsAntineoplastic AgentsAptamers, NucleotideFibroinsGoldApoptosisAptamer, gold nanocompositesLiver cancerSilk fibroin

Identifiers

PMID38676857
OpenAlexW4395690727

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.