Evidence map›Paper›PMID 38676843›Full record

ArticleJournal of assisted reproduction and genetics2024

Fertility preservation in males with cancer of trends, region development, and efficacy in mainland China from 16 regions Chinese sperm banks.

Xiao Liu, Qiling Wang, Huiqiang Sheng, Xiaowei Liang, Zhiqiang Wang, Tianqing Meng, Yushan Li, Hao Dong, Wenbing Zhu, Jigao Yang and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 1 country.

Xiao Liu *Department of Andrology/Sichuan Human Sperm Bank, West China Second University Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0001-8718-206X
Qiling Wang *NHC Key Laboratory of Male Reproduction and Genetics Guangdong Provincial Reproductive, Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou, 510062, Guangdong, China.
Huiqiang ShengZhejiang Mater Child and Reproductive Health Center, Hangzhou, 310000, Zhejiang, China.
Xiaowei LiangHuman Sperm Bank of National Research Institute for Family Planning, Beijing, 100098, China.
Zhiqiang WangThe First Affiliated Hospital of Guangxi Medical University, Guilin, 530021, Guangxi, China.
Tianqing MengHubei Province Human Sperm Bank, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430010, Hubei, China.
Yushan LiHenan Human Sperm Bank, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, Henan, China.
Hao DongDepartment of Urological Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
Wenbing ZhuReproductive & Genetic Hospital of CITIC-Xiangya, Changsha, 410008, Hunan, China.
Jigao YangChongqing Research Institute for Population and Family Planning Science and Technology, Human Sperm Bank, Chongqing, 401121, China.
Zhou ZhangNorthwest Women's and Children's Hospital, Xian, 610045, Shaanxi, China.
Xianglong JiangNanchang Reproductive Hospital, Nanchang, 330001, Jiangxi, China.
Aiping ZhangHuman Sperm Bank of The First Hospital of Lanzhou University, Lanzhou, 730099, Gansu, China.
Zuowen LiangThe First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Xiaojin HeAnhui Provincial Human Sperm Bank, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
Chunying SongShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Sperm Bank, Taiyuan, 030001, Shanxi, China.
Fuping LiDepartment of Andrology/Sichuan Human Sperm Bank, West China Second University Hospital, Sichuan University, Chengdu, China. lfpsnake@scu.edu.cn.
Xinzong ZhangNHC Key Laboratory of Male Reproduction and Genetics Guangdong Provincial Reproductive, Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou, 510062, Guangdong, China. 13857170787@139.com.
Sichuan University · CNAnhui Medical University · CNChongqing Population and Family Planning Science and Technology Research Institute · CNFirst Hospital of Lanzhou University · CNGuangdong Provincial People's Hospital · CNGuangxi Medical University · CNHuazhong University of Science and Technology · CNJiangxi Maternal and Child Health Hospital · CNJilin University · CNKunming Medical University · CNNorthwest Women's and Children's Hospital · CNReproductive & Genetic Hospital CITIC-Xiangya · CNShanxi Academy of Medical Sciences · CNThird Affiliated Hospital of Zhengzhou University · CN

Funding

Department of Natural Resources of Guangdong Province 2021A1515011544Guangzhou Municipal Science and Technology Bureau 202002030480Sichuan Science and Technology Program 2022YFS0045
6 · The paper itself

Abstract

purposeMale cancer survivors experience confusion about fertility following cancer treatment. The aims of this study were to evaluate survivors' semen quality in different tumor type groups in China and to analyze the current situation and challenges of male cancer patients with sperm cryopreservation.

methodsThis was a multicenter retrospective study of male patients with cancer who underwent sperm cryopreservation in 16 regions of the national sperm banks over an 11-year period from 2010 to 2020.

resultsThe number of male cancer patients with sperm cryopreservation showed an overall upward trend. The development of male cancer fertility preservation (FP) in the eastern, central, and western regions of Chinese displayed imbalance. There are seven tumor types for sperm preservation in the top incidence ten tumor types, including lymphoma, leukemia, nasopharyngeal carcinoma, sarcoma, thyroid cancer, and brain tumor. Moreover, nasopharyngeal carcinoma is a high incidence rate in China, which is related to high sperm preservation rate, different from other countries. The most percentage of males receiving sperm cryopreservation in the testicular cancers (15-39 years old) of China in 2020 was 5.55%, 1.29% in the lymphoma, and 0.39% in the leukemia. According to the type of cancer, a statistically significant lower pre-sperm density, total sperm output, and post-sperm density was observed in testicular cancers. It is worth noting that the prevalence of azoospermia 22.2% in leukemia patients attribute to urgent treatment before sperm cryopreservation. Disposition of cryopreserved sperm categories included continued storage (47.2%), discarded (9%), death (0.9%), and use (3.7%).

conclusionThis study provides the first comprehensive national statistical census and review of fertility preservation in male cancer patients with respect to trends, prevalence, and cancer types. The development of male cancer fertility preservation in China is imbalanced and percentage of males receiving sperm cryopreservation in the adolescent and young adult cancers was low. Sixteen human sperm banks from China analyze current problems and challenges, and then prioritize steps toward the achievement of the FP strategy framework for Healthy China 2030.

Indexed as

CryopreservationFertility PreservationNeoplasmsSemen PreservationSperm BanksAdolescentAdultChinaEast Asian PeopleHumansInfertility, MaleMaleRetrospective StudiesSemen AnalysisSpermatozoaYoung AdultFertility preservationMale cancerSemen qualitySperm cryopreservation

Identifiers

PMID38676843
PMCPMC11263528
OpenAlexW4395695503

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.