Evidence map›Paper›PMID 38676817›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

A non-linear relationship between blood pressure and mild cognitive impairment in elderly individuals: A cohort study based on the Chinese longitudinal healthy longevity survey (CLHLS).

Fuliang Yi, Yang Gao, Xin Liu, Yujuan Ying, Qiaojin Xie, You You, Qian Zha, Canjing Luo, Min Ni, Qiuping Wang and 1 more

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Fuliang YiHealth Management Center, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, 643000, People's Republic of China.
Yang GaoHealth Management Center, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, 643000, People's Republic of China.
Xin LiuHealth Management Center, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, 643000, People's Republic of China.
Yujuan YingHealth Management Center, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, 643000, People's Republic of China.
Qiaojin XieHealth Management Center, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, 643000, People's Republic of China.
You YouHealth Management Center, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, 643000, People's Republic of China.
Qian ZhaHealth Management Center, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, 643000, People's Republic of China.
Canjing LuoHealth Management Center, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, 643000, People's Republic of China.
Min NiHealth Management Center, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, 643000, People's Republic of China.
Qiuping WangHealth Management Center, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, 643000, People's Republic of China.
Yuanfang ZhuHealth Management Center, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, 643000, People's Republic of China. 13990039886@163.com.ORCID http://orcid.org/0009-0005-3645-9395
Zigong First People's Hospital · CN

Funding

Key Science and Technology Program Projects of Zigong 2022ZCNKY19
6 · The paper itself

Abstract

backgroundHypertension is an established risk factor for mild cognitive impairment (MCI) in elderly individuals. Nevertheless, the impact of different levels of blood pressure on the progression of MCI remains uncertain. This study aims to investigate the non-linear relationship between blood pressure and MCI in the elderly and detect the critical blood pressure threshold, thus, improving blood pressure management for individuals at high risk of MCI.

methodsData was obtained from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) cohort. We chose normal cognitive elderly individuals who entered the cohort in 2014 for a 5-year follow-up to observe the progression of MCI. Subsequently, we utilized the Cox regression model to identify risk factors for MCI and conducted a Cox-based restricted cubic spline regression (RCS) model to examine the non-linear relationship between systolic blood pressure (SBP) and diastolic blood pressure (DBP) with MCI, determining the critical blood pressure threshold for MCI progression.

resultsIn the elderly population, female (HR = 1.489, 95% CI: 1.017-2.180), lacking of exercise in the past (HR = 1.714, 95% CI: 1.108-2.653), preferring animal fats (HR = 2.340, 95% CI: 1.348-4.061), increased age (HR = 1.061, 95% CI: 1.038-1.084), increased SBP (HR = 1.036, 95% CI: 1.024-1.048), and increased DBP (HR = 1.056, 95% CI: 1.031-1.081) were associated with MCI progression. After adjusting factors such as gender, exercise, preferred types of fats, and age, both SBP (P

conclusionIn this study, we discovered that risk factors affecting the progression of MCI in elderly individuals comprise gender (female), preferring to use animal fat, lack of exercise in the past, increased age, increased SBP, and increased DBP. Additionally, a non-linear relationship between blood pressure levels and MCI progression was confirmed, with the critical blood pressure management threshold for MCI onset falling within the prehypertensive range.

Indexed as

Blood PressureCognitive DysfunctionDisease ProgressionAgedAged, 80 and overChinaCohort StudiesEast Asian PeopleFemaleHumansHypertensionLongevityLongitudinal StudiesMaleRisk FactorsBlood pressure levelsElderly individualsMild cognitive impairmentNon-linear relationship

Identifiers

PMID38676817
OpenAlexW4395694755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.