Development of Orthotopic Patient-Derived Xenograft Models of Pediatric Intracranial Tumors.

Dannielle H Upton, David S Ziegler, Maria Tsoli

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact, top 84% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dannielle H UptonChildren's Cancer Institute Australia, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.

David S ZieglerChildren's Cancer Institute Australia, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia. d.ziegler@unsw.edu.au.

Maria TsoliChildren's Cancer Institute Australia, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia. MTsoli@ccia.org.au.

UNSW Sydney · AU

Funding

National Health and Medical Research Council #2019056

6 · The paper itself

Abstract

The development of clinically relevant and reliable models of central nervous system tumors has been instrumental in advancing the field of Neuro-Oncology. The orthotopic intracranial injection is widely used to study the growth, invasion, and spread of tumors in a controlled environment. Orthotopic models are performed to examine tumor cells isolated from a specific region in a patient in the same site or location in an animal model. Orthotopic brain tumor models are also utilized for preclinical testing of therapeutics as they closely recapitulate the behavior of such cancer and the brain environment of patients. Below, we describe our experiences in the development of murine models of pediatric brain tumors including diffuse midline glioma (DMG), glioblastoma (GBM), and medulloblastoma. The method provides an overview of intracranial stereotactic injections in mice.

Indexed as

Brain NeoplasmsDisease Models, AnimalAnimalsChildGlioblastomaGliomaHeterograftsHumansMedulloblastomaMiceXenograft Model Antitumor AssaysDiffuse midline gliomaDMGGBMGlioblastomaIntracranial tumorMedulloblastomaOrthotopic modelOrthotopic xenograft modelPatient-derived xenograftPediatricPrecision medicineStereotactic injectionTranslational

Identifiers

PMID38676797

DOI10.1111/j.1750-3639.2008.00234.x

OpenAlexW4395698799

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.