Evidence map›Paper›PMID 38676795›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain Cancers.

Jessica Buck, Hilary Hii, Raelene Endersby

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jessica BuckBrain Tumor Research Program, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia.
Hilary HiiBrain Tumor Research Program, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia.
Raelene EndersbyBrain Tumor Research Program, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia. Raelene.endersby@telethonkids.org.au.
The Kids Research Institute Australia · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patient-derived orthotopic xenograft (PDOX) mouse models are considered the gold standard for evidence-based preclinical research in pediatric neuro-oncology. This protocol describes the generation of PDOX models by intracranial implantation of human pediatric brain cancer cells into immune-deficient mice, and their continued propagation to establish cohorts of animals for preclinical research.

Indexed as

Brain NeoplasmsDisease Models, AnimalAnimalsChildHeterograftsHumansMiceNeoplasm GradingXenograft Model Antitumor AssaysMouse models of cancerPatient-derived xenograftPediatric brain cancerPreclinical models

Identifiers

PMID38676795
OpenAlexW4395698837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.