A Novel NIR Fluorescence Probe with AIE Property to Image Viscosity in Nystatin-Induced Cell Model.

Xiaokai Wang, Zhan Yin, Haoran Liu, Ziming Wang, Xiaofei Zhu, Yong Ye

Abstract read

In one paragraph

Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

1.4field-weighted citation impact, top 21% of its field

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3 · Its place in the literature

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0 citing papers in PubMed, 6 citations in OpenAlex.

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5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiaokai WangGreen Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.

Zhan YinGreen Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.

Haoran LiuGreen Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.

Ziming WangGreen Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.

Xiaofei ZhuGreen Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China. Zhuxiaofei@zzu.edu.cn.

Yong YeGreen Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China. yeyong03@tsinghua.org.cn.

Zhengzhou University · CN

Funding

National Natural Science Foundation of China 21907025

6 · The paper itself

Abstract

As one of the most significant parameters in cellular microenvironment, viscosity levels could be used to determine the metabolic process of bioactive substances within cells. Abnormal viscosity levels are closely associated with a series of diseases. Therefore, the design and synthesis of fluorescent probes that can monitor changes of intracellular viscosity in real-time is of great significance for the study of disease development process. Here, a new viscosity-recognized NIR fluorescence probe W1 based on quinoline-malonitrile is synthesized, and it is not susceptible to interference substances. Besides, AIE probe W1 shows fast response, excellent photostability, low cytotoxicity, good linear relationship between fluorescence intensity value and viscosity. Based on the above advantages, probe W1 is used to image the change of viscosity level in the cell model induced by nystatin.

Indexed as

Fluorescent DyesNystatinOptical ImagingCell SurvivalHumansInfrared RaysMolecular StructureQuinolinesViscosityFluorescent DyesNystatinQuinolinesAIEFluorescence probeImageNIRViscosity

Identifiers

PMID38676771

DOI10.1007/s10895-024-03706-9

OpenAlexW4395701281

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.