Evidence map›Paper›PMID 38676529›Full record

ArticleCurrent medicinal chemistry2024

Differential Effect of 4

Ixamail Fraire-Soto, Jorge Gustavo Araujo-Huitrado, Angelica Judith Granados-López, Luis A Segura-Quezada, Rafael Ortiz-Alvarado, Mayra Denise Herrera, Rosalinda Gutiérrez-Hernández, Claudia Araceli Reyes-Hernández, Yamilé López-Hernández, Melissa Tapia-Juárez and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Current medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Ixamail Fraire-SotoLaboratorio de MicroRNAs y Cáncer, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Agronómica, Campus II, Zacatecas, Zac., 98066, México.
Jorge Gustavo Araujo-HuitradoLaboratorio de MicroRNAs y Cáncer, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Agronómica, Campus II, Zacatecas, Zac., 98066, México.
Angelica Judith Granados-LópezLaboratorio de MicroRNAs y Cáncer, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Agronómica, Campus II, Zacatecas, Zac., 98066, México.
Luis A Segura-QuezadaDepartamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Noria Alta S/N, Guanajuato, 36050, México.
Rafael Ortiz-AlvaradoDepartamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Noria Alta S/N, Guanajuato, 36050, México.
Mayra Denise HerreraLaboratorio de MicroRNAs y Cáncer, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Agronómica, Campus II, Zacatecas, Zac., 98066, México.
Rosalinda Gutiérrez-HernándezLaboratorio de MicroRNAs y Cáncer, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Agronómica, Campus II, Zacatecas, Zac., 98066, México.
Claudia Araceli Reyes-HernándezLaboratorio de MicroRNAs y Cáncer, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Agronómica, Campus II, Zacatecas, Zac., 98066, México.
Yamilé López-HernándezLaboratorio de Metabolómica y Proteómica Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Agronómica, Campus II, Zacatecas, Zac., 98066, México.
Melissa Tapia-JuárezLaboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria, Morelia, Mich., 58033, México.
José Vicente Negrete-DíazLaboratory of Brain Plasticity and Integrative Neuroscience, Program of Clinical Psychology, University of Guanajuato, Guanajuato, 38060, México.
Luis Chacón-GarcíaLaboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria, Morelia, Mich., 58033, México.
César R Solorio-AlvaradoDepartamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Campus Guanajuato, Noria Alta S/N, Guanajuato, 36050, México.
Jesús Adrián LópezLaboratorio de MicroRNAs y Cáncer, Universidad Autónoma de Zacatecas, Av. Preparatoria S/N, Agronómica, Campus II, Zacatecas, Zac., 98066, México.ORCID 0000-0001-8012-7041
Universidad Autónoma de Zacatecas "Francisco García Salinas" · MXUniversidad de Guanajuato · MXUniversidad Michoacana de San Nicolás de Hidalgo · MXInstituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias · MX

Funding

Consejo Nacional de Ciencia y Tecnología PRONACES/610286/2020,FIDCC 2022/321616
6 · The paper itself

Abstract

backgroundA family of 4

methodThe precursors and oxazines obtained were studied in breast cancer cell lines MCF-7, CAMA-1, HCC1954 and SKBR-3 with differential biological activity showing various degrees of inhibition with a notable effect for those that had an aryl substituted at C-2 of the molecules. 4

resultsWe observed that etoposide is similar to benzoxazines while taxol effect is more potent. Four cell lines responded to benzoxazines while SKBR-3 cell line responded to precursors and benzoxazines. Compounds 16, 24, 25 and 26 have the potent effect in cell proliferation inhibition in the 4 cell lines tested and correlated with oxidant activity suggesting a possible mechanism by ROS generation.

conclusionThese compounds represent possible drug candidates for the treatment of breast cancer. However, further trials are needed to elucidate its full effect on cellular and molecular features of cancer.

Indexed as

Antineoplastic AgentsBenzoxazinesBreast NeoplasmsCell ProliferationCell Line, TumorDrug Screening Assays, AntitumorFemaleHumansMolecular StructureReactive Oxygen SpeciesStructure-Activity RelationshipAntineoplastic AgentsBenzoxazinesReactive Oxygen SpeciesbenzoxazinesBreast cancercell linesoxidationproliferationreduction.

Identifiers

PMID38676529
OpenAlexW4395695274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.