Evidence map›Paper›PMID 38676509›Full record

ReviewCurrent diabetes reviews2025

Probiotic Supplementation during Pregnancy: Evaluating the Current Clinical Evidence against Gestational Diabetes Mellitus.

Eleni Pavlidou, Olga Alexatou, Gerasimos Tsourouflis, Georgios Antasouras, Sousana K Papadopoulou, Dimitrios Papandreou, Anastasia Sampani, Constantinos Giaginis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current diabetes reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eleni PavlidouDepartment of Food Science and Nutrition, School of Environment, University of Aegean, Myrina, Lemnos, 81400, Greece.ORCID 0000-0002-7764-3544
Olga AlexatouDepartment of Food Science and Nutrition, School of Environment, University of Aegean, Myrina, Lemnos, 81400, Greece.
Gerasimos TsourouflisSecond Department of Propedeutic Surgery, Medical School, University of Athens, 11527 Athens, Greece.
Georgios AntasourasDepartment of Food Science and Nutrition, School of Environment, University of Aegean, Myrina, Lemnos, 81400, Greece.
Sousana K PapadopoulouDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece.
Dimitrios PapandreouDepartment of Clinical Nutrition & Dietetics, College of Health University of Sharjah, P.O Box 27272, United Arab Emirates.
Anastasia SampaniFirst Department of Pathology, Medical School, University of Athens, 11527, Athens, Greece.
Constantinos GiaginisDepartment of Food Science and Nutrition, School of Environment, University of Aegean, Myrina, Lemnos, 81400, Greece.ORCID 0000-0003-2878-4831

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGestational diabetes mellitus (GDM) constitutes a common metabolic disorder that could lead to deleterious short- and long-term complications in both the mother and her infant. Probiotic supplementation seems to exert diverse, healthy effects by acting as a preventive agent against various human diseases, including GDM.

objectiveThe purpose of the current narrative review was to critically summarize and scrutinize the available clinical studies during the last 15 years (2008-2023) concerning the use of probiotic supplementation during pregnancy as a protecting agent against GDM.

methodsA thorough and in-depth search was performed in the most accurate scientific databases, e.g., PubMed., Scopus, Web of Science, and Google Scholar applying effective, and relevant keywords.

resultsThere are currently some clinical studies suggesting the potential beneficial impact of probiotic supplementation in the prevention and/or co-treatment of GDM. Nevertheless, there is a high heterogeneity amongst the available clinical studies concerning the dosage, the administration duration, the probiotic species types, the method designs and protocols, and the study populations.

conclusionProbiotic supplementation at conventional dosages and in combination with a balanced healthy diet, and lifestyle seems to reduce the the risk of developing GDM, while ameliorating the severity of its symptoms. Further clinical studies taking into account the above considerations should be performed to establish conclusive results, while the future meta-analyses should include studies with the feasibly lowest heterogeneity.

Indexed as

Diabetes, GestationalDietary SupplementsProbioticsFemaleHumansPregnancyclinical studiesfasting glycose levelsgestational diabetesinsulin resistancepregnancypreventionProbioticssupplementationtreatment.

Identifiers

PMID38676509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.