Evidence map›Paper›PMID 38676310›Full record

ArticlePhotodermatology, photoimmunology & photomedicine2024

Inhibition of UVB radiation-induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene.

Verena Isak, Shayan Azizi, Xi K Zhou, Devina Mehta, Wanhong Ding, Zakir Bulmer, Daniella S Aivazi, Ryan W Dellinger, Richard D Granstein

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photodermatology, photoimmunology & photomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Verena IsakDepartment of Dermatology, Weill Cornell Medicine, New York, New York, USA.
Shayan AziziDepartment of Dermatology, Weill Cornell Medicine, New York, New York, USA.
Xi K ZhouDepartment of Population Health Sciences, Weill Cornell Medicine, New York, New York, USA.
Devina MehtaDepartment of Dermatology, Weill Cornell Medicine, New York, New York, USA.
Wanhong DingDepartment of Dermatology, Weill Cornell Medicine, New York, New York, USA.
Zakir BulmerDepartment of Dermatology, Weill Cornell Medicine, New York, New York, USA.
Daniella S AivaziDepartment of Dermatology, Weill Cornell Medicine, New York, New York, USA.
Ryan W DellingerElysium Health, Inc., New York, New York, USA.
Richard D GransteinDepartment of Dermatology, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0003-2824-7411
Cornell University · USElysium Therapeutics (United States) · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002384NIH HHS UL1TR002384
6 · The paper itself

Abstract

backgroundEnvironmental ultraviolet radiation has deleterious effects on humans, including sunburn and immune perturbations. These immune changes are involved in skin carcinogenesis.

objectivesTo determine whether nicotinamide riboside and/or pterostilbene administered systemically inhibits inflammatory and immune effects of exposure to mid-range ultraviolet radiation.

methodsTo examine UVB radiation-induced inflammatory effects, mice were fed standard chow/water, 0.04% pterostilbene in chow and 0.2% nicotinamide riboside in drinking water, diet with nicotinamide riboside alone, or diet with pterostilbene alone. After 4 weeks, mice were exposed to UVB radiation (3500 J/m

resultsNicotinamide riboside and pterostilbene together inhibited UVB-induced skin swelling more than either alone. Pterostilbene alone and both given together could inhibit UVB-induced immune suppression in both the low-dose and high-dose models while nicotinamide riboside alone was more effective in the low-dose model than the high-dose model.

conclusionNicotinamide riboside and pterostilbene have protective effects against UVB radiation-induced tissue swelling and immune suppression.

Indexed as

NiacinamidePyridinium CompoundsStilbenesUltraviolet RaysAnimalsDermatitis, ContactFemaleMiceNiacinamidenicotinamide-beta-ribosidepterostilbenePyridinium CompoundsStilbenesanimal modelimmunityinflammationultraviolet radiation

Identifiers

PMID38676310
PMCPMC11077400
OpenAlexW4395693358

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.