Evidence map›Paper›PMID 38675981›Full record

ArticleViruses2024

Monitoring HPV Prevalence and Risk Cofactors for Abnormal Cytology in the Post-Vaccination Period among Croatian Women.

Ena Pešut, Ivana Šimić, Rajko Fureš, Nina Milutin Gašperov, Cvjetko Lež, Fabijan Feratović, Tomica Kukina Žvigač, Magdalena Grce, Ivana Erceg Ivkošić, Ivan Sabol

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. HPV Type Replacement After HPV Vaccination.Current topics in microbiology and immunology · 2026
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ena PešutDivision of Molecular Medicine, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia.ORCID 0000-0001-5409-6034
Ivana ŠimićDivision of Molecular Medicine, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia.ORCID 0000-0002-7816-3534
Rajko FurešGeneral Hospital Zabok, Bračak 8, 49210 Zabok, Croatia.ORCID 0000-0001-6494-0972
Nina Milutin GašperovDivision of Molecular Medicine, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia.ORCID 0000-0002-6219-7836
Cvjetko LežGeneral Hospital Zabok, Bračak 8, 49210 Zabok, Croatia.
Fabijan FeratovićGeneral Hospital Zabok, Bračak 8, 49210 Zabok, Croatia.
Tomica Kukina ŽvigačGeneral Hospital Zabok, Bračak 8, 49210 Zabok, Croatia.ORCID 0009-0008-3735-6621
Magdalena GrceDivision of Molecular Medicine, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia.ORCID 0000-0001-6178-8418
Ivana Erceg IvkošićFaculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University Osijek, Crkvena 21, 31000 Osijek, Croatia.
Ivan SabolDivision of Molecular Medicine, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia.ORCID 0000-0002-5753-8528
Ruđer Bošković Institute · HRZabok General Hospital · HRKlinička bolnica "Sveti Duh" · HRUniversity of Rijeka · HR

Funding

Croatian Science Foundation IP-2019-04-3403
6 · The paper itself

Abstract

The incidence and mortality rate of cervical cancer in Croatia remains a health challenge despite screening efforts. Besides the persistent infection with HPV, the development of cancer is also associated with some cofactors. The goal of this study was to assess circulating HPV genotypes and risk factors for the development of cervical precancer after almost 16 years from the onset of HPV vaccination in Croatia. In this study, a total of 321 women attending gynecological care were evaluated. Relevant medical and demographic information, including cytology, were collected. HPV genotyping was performed by PCR. Comparing the HPV types found in circulation in the pre-vaccination (1999-2015) and post-vaccination periods (2020-2023), a statistically significant reduction in HPV 31 was noted, while the overall prevalence increased in the post-vaccination period. Besides the expected HPV positivity as a risk factor, the history of smoking was associated with LSIL or worse cytology at enrollment. For the first time, this population study revealed a statistically significant shift in the HPV genotype in the post-vaccination period, as well as the confirmation of risk factors for the development of abnormal cytology among Croatian women.

Indexed as

GenotypePapillomaviridaePapillomavirus InfectionsPapillomavirus VaccinesUterine Cervical NeoplasmsAdultCroatiaFemaleHumansMiddle AgedPrevalenceRisk FactorsVaccinationYoung AdultPapillomavirus Vaccinescervical cancerHPVprevalencescreeningvaccination

Identifiers

PMID38675981
PMCPMC11054414
OpenAlexW4394999338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.