Evidence map›Paper›PMID 38675904›Full record

ArticleViruses2024

Nicotinic Acetylcholine Receptor Alpha6 Contributes to Antiviral Immunity via IMD Pathway in

Zhiying Wang, Xiaoju Lin, Wangpeng Shi, Chuan Cao

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhiying WangDepartment of Entomology, China Agricultural University, Beijing 100193, China.ORCID 0009-0005-8309-7796
Xiaoju LinDepartment of Entomology, China Agricultural University, Beijing 100193, China.
Wangpeng ShiDepartment of Entomology, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-9701-5326
Chuan CaoDepartment of Entomology, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-0320-1110
China Agricultural University · CN

Funding

National Natural Science Foundation of China 32000341
6 · The paper itself

Abstract

Currently, insecticides that target nicotinic acetylcholine receptors (nAChR) are widely used. Studies on the sublethal effects of insecticides have found that they can affect the amount of virus in insects. The mechanism by which insecticides affect insect virus load remain unclear. Here, we show that nAChR targeting insecticide can affect viral replication through the immune deficiency (IMD) pathway. We demonstrate that a low dose of spinosad (6.8 ng/mL), acting as an antagonist to

Indexed as

Drosophila melanogasterDrosophila ProteinsReceptors, NicotinicAnimalsDrug CombinationsImmunity, InnateInsecticidesMacrolidesSignal TransductionViral LoadVirus ReplicationDrosophila ProteinsDrug CombinationsInsecticidesMacrolidesnicotinic receptor alpha6Receptors, Nicotinicspinosadantiviral immunityIMD pathwayinsecticidenicotinic acetylcholine receptors

Identifiers

PMID38675904
PMCPMC11054842
OpenAlexW4393899338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.