Evidence map›Paper›PMID 38675895›Full record

ArticleViruses2024

A Comparative Study of Human Pluripotent Stem Cell-Derived Macrophages in Modeling Viral Infections.

Yaxuan Zhang, Hui Qiu, Fuyu Duan, Haoran An, Huimin Qiao, Xingwu Zhang, Jing-Ren Zhang, Qiang Ding, Jie Na

Open access · goldAbstract readComparative Study
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yaxuan ZhangCenter for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-2468-8896
Hui QiuCenter for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing 100084, China.
Fuyu DuanCenter for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing 100084, China.ORCID 0000-0001-5628-5226
Haoran AnCenter for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-5921-7402
Huimin QiaoCenter for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 100084, China.
Xingwu ZhangCenter for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-5472-1706
Jing-Ren ZhangCenter for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 100084, China.
Qiang DingCenter for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 100084, China.
Jie NaCenter for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-1820-0548
Tsinghua University · CNPeking University · CNGuangzhou Medical University · CNShanxi Medical University · CN

Funding

Boehringer Ingelheim (China) Boehringer Ingelheim-Tsinghua Immunoinfection Research Center Grant No. 346515-13Ministry of Science and Technology of the People's Republic of China National Key R&D Program of China Nos. 2022YFA1103103 and 2019YFA0110001National Natural Science Foundation of China Nos. 32270784 and 31970819 to Jie NaTsinghua University Spring Breeze Fund No. 2021Z99CFY033
6 · The paper itself

Abstract

Macrophages play multiple roles in innate immunity including phagocytosing pathogens, modulating the inflammatory response, presenting antigens, and recruiting other immune cells. Tissue-resident macrophages (TRMs) adapt to the local microenvironment and can exhibit different immune responses upon encountering distinct pathogens. In this study, we generated induced macrophages (iMACs) derived from human pluripotent stem cells (hPSCs) to investigate the interactions between the macrophages and various human pathogens, including the hepatitis C virus (HCV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and

Indexed as

HepacivirusMacrophagesPluripotent Stem CellsSARS-CoV-2COVID-19Hepatitis CHumansImmunity, InnatePhagocytosisStreptococcus pneumoniaeVirus Diseaseshepatitis C virushuman pluripotent stem cellinfectionmacrophageSARS-CoV-2

Identifiers

PMID38675895
PMCPMC11053470
OpenAlexW4393388260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.