Evidence map›Paper›PMID 38675891›Full record

ArticleViruses2024

Pandemic Risk Assessment for Swine Influenza A Virus in Comparative In Vitro and In Vivo Models.

Ian Padykula, Lambodhar Damodaran, Kelsey T Young, Madelyn Krunkosky, Emily F Griffin, James F North, Peter J Neasham, Vasilis C Pliasas, Chris L Siepker, James B Stanton and 4 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Interplay between respiratory viruses and cilia in the airways.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ian PadykulaCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0003-2889-1864
Lambodhar DamodaranDepartment of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Kelsey T YoungDepartment of Pathology, University of Georgia, Athens, GA 30602, USA.
Madelyn KrunkoskyCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.ORCID 0009-0008-5340-7548
Emily F GriffinCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0001-5616-8118
James F NorthEmory-UGA Centers of Excellence for Influenza Research and Surveillance (CEIRS), Athens, GA 30602, USA.
Peter J NeashamEmory-UGA Centers of Excellence for Influenza Research and Surveillance (CEIRS), Athens, GA 30602, USA.
Vasilis C PliasasEmory-UGA Centers of Excellence for Influenza Research and Surveillance (CEIRS), Athens, GA 30602, USA.
Chris L SiepkerDepartment of Pathology, University of Georgia, Athens, GA 30602, USA.
James B StantonDepartment of Pathology, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-7661-2631
Elizabeth W HowerthDepartment of Pathology, University of Georgia, Athens, GA 30602, USA.
Justin BahlDepartment of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0001-7572-4300
Constantinos S KyriakisEmory-UGA Centers of Excellence for Influenza Research and Surveillance (CEIRS), Athens, GA 30602, USA.
Stephen Mark TompkinsCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-1523-5588
University of Georgia · USCenter for Surveillance, Epidemiology, and Laboratory Services · US

Funding

NIAID NIH HHS HHSN272201400004C
6 · The paper itself

Abstract

Swine influenza A viruses pose a public health concern as novel and circulating strains occasionally spill over into human hosts, with the potential to cause disease. Crucial to preempting these events is the use of a threat assessment framework for human populations. However, established guidelines do not specify which animal models or in vitro substrates should be used. We completed an assessment of a contemporary swine influenza isolate, A/swine/GA/A27480/2019 (H1N2), using animal models and human cell substrates. Infection studies in vivo revealed high replicative ability and a pathogenic phenotype in the swine host, with replication corresponding to a complementary study performed in swine primary respiratory epithelial cells. However, replication was limited in human primary cell substrates. This contrasted with our findings in the Calu-3 cell line, which demonstrated a replication profile on par with the 2009 pandemic H1N1 virus. These data suggest that the selection of models is important for meaningful risk assessment.

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza, HumanOrthomyxoviridae InfectionsVirus ReplicationAnimalsCell LineDisease Models, AnimalDogsEpithelial CellsFemaleHumansInfluenza A Virus, H1N2 SubtypeMicePandemicsRisk AssessmentSwineanimalepithelial cellsferretshumansinfluenza A virusmicemodelspandemicsrisk assessmentswinewhole genome sequencing

Identifiers

PMID38675891
PMCPMC11053818
OpenAlexW4393356949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.