Evidence map›Paper›PMID 38675881›Full record

ArticleViruses2024

Vaccination against Rabbit Hemorrhagic Disease Virus 2 (RHDV2) Using a Baculovirus Recombinant Vaccine Provides Durable Immunity in Rabbits.

Angela M Bosco-Lauth, Amber Schueler, Edward Midthun, Hailey Tyra, Amanda Held, Claire Hood, Marissa Quilici, Sara Erickson, Sherry Glover, Bradley Gustafson and 1 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Angela M Bosco-LauthDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Amber SchuelerMedgene, Brookings, SD 57006, USA.
Edward MidthunDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Hailey TyraDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Amanda HeldDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Claire HoodDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Marissa QuiliciDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Sara EricksonMedgene, Brookings, SD 57006, USA.
Sherry GloverMedgene, Brookings, SD 57006, USA.
Bradley GustafsonMedgene, Brookings, SD 57006, USA.
Gary AndersonMedgene, Brookings, SD 57006, USA.
Colorado State University · US

Funding

Medgene Labs (United States) 011619-00002
6 · The paper itself

Abstract

Rabbit hemorrhagic disease virus 2 (RHDV2) emerged in the United States in 2018 and has spread in both domestic and wild rabbits nationwide. The virus has a high mortality rate and can spread rapidly once introduced in a rabbit population. Vaccination against RHDV2 provides the best protection against disease and should be considered by all rabbit owners. Here, we investigate the duration of immunity provided by vaccination with the Medgene Platform conditionally licensed commercial vaccine 6 months following the initial series. Rabbits received either the vaccination or a placebo and were challenged with RHDV2 6 months later. All vaccinated rabbits survived challenge whereas 18/19 non-vaccinated controls succumbed to infection within 10 or fewer days post-challenge. These results demonstrate lasting immunity following vaccination with the Medgene RHDV2 vaccine.

Indexed as

BaculoviridaeCaliciviridae InfectionsHemorrhagic Disease Virus, RabbitVaccinationVaccines, SyntheticViral VaccinesAnimalsAntibodies, ViralRabbitsAntibodies, ViralVaccines, SyntheticViral Vaccinesdomestic rabbitrabbit hemorrhagic disease virus 2RHDV2vaccine

Identifiers

PMID38675881
PMCPMC11054048
OpenAlexW4393356782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.