Evidence map›Paper›PMID 38675812›Full record

ArticleVaccines2024

STAT1-Deficient HPV E6/E7-Associated Cancers Maintain Host Immunocompetency against Therapeutic Intervention.

Ling Lim, Ming-Hung Hu, Darrell Fan, Hsin-Fang Tu, Ya-Chea Tsai, Michelle Cheng, Suyang Wang, Chih-Long Chang, Tzyy-Choou Wu, Chien-Fu Hung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Frontiers in immunology · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Ling LimDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0001-7555-6394
Ming-Hung HuDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0002-9923-0281
Darrell FanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Hsin-Fang TuDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Ya-Chea TsaiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Michelle ChengDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0009-0009-3158-8226
Suyang WangDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0009-0002-9139-1723
Chih-Long ChangDepartment of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei 104217, Taiwan.ORCID 0000-0003-3981-9366
Tzyy-Choou WuDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Chien-Fu HungDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Johns Hopkins University · USMackay Memorial Hospital · TW

Funding

Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI WARNER KING HUH, TZYY-CHOOU WU · 2003 to 2026
$53.5M
Development of Novel Spontaneous HPV Cervicovaginal Carcinoma Models for Cancer ImmunotherapyR01CA237067 · NCI · JOHNS HOPKINS UNIVERSITY · PI WU, TZYY-CHOOU · 2019 to 2023
$2.9M
Albumin-FMS-like tyrosine kinase 3 ligand (Alb-Flt3L) fusion protein as a novel adjuvant to enhance the immunogenicity and therapeutic and prophylactic efficacies of a HPV protein vaccineR21CA234516 · NCI · JOHNS HOPKINS UNIVERSITY · PI HUNG, CHIEN-FU · 2020 to 2021
$421k
Novel strategy combined with targeted radiation therapy unleashes potentantitumor immunity in HPV + head and neck cancerR21CA256020 · NCI · JOHNS HOPKINS UNIVERSITY · PI HUNG, CHIEN-FU · 2021 to 2022
$417k
NCI NIH HHS 1R21CA234516-01A1NCI NIH HHS P50CA098252NCI NIH HHS R01CA237067NCI NIH HHS R21CA256020NCI NIH HHS R21DE029910-01
6 · The paper itself

Abstract

Human papillomavirus (HPV) remains a global health concern because it contributes to the initiation of various HPV-associated cancers such as anal, cervical, oropharyngeal, penile, vaginal, and vulvar cancer. In HPV-associated cancers, oncogenesis begins with an HPV infection, which is linked to the activation of the Janus protein tyrosine kinase (JAK)/STAT signaling pathway. Various STAT signaling pathways, such as STAT3 activation, have been well documented for their tumorigenic role, yet the role of STAT1 in tumor formation remains unclear. In the current study, STAT1

Indexed as

E6/E7human papillomavirusimmunitySTAT1T cells

Identifiers

PMID38675812
PMCPMC11053987
OpenAlexW4394891938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.