Evidence map›Paper›PMID 38675791›Full record

ArticleVaccines2024

Nanocapsules Comprised of Purified Protein: Construction and Applications in Vaccine Research.

Ivana Skakic, Aya C Taki, Jasmine E Francis, Chaitali Dekiwadia, Thi Thu Hao Van, Carina C D Joe, Tram Phan, George Lovrecz, Paul R Gorry, Paul A Ramsland and 2 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Vaccines · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ivana SkakicSchool of Science, RMIT University, 264 Plenty Road, Bundoora, VIC 3083, Australia.
Aya C TakiMelbourne Veterinary School, Faculty of Science, The University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0003-3489-4367
Jasmine E FrancisSchool of Science, RMIT University, 264 Plenty Road, Bundoora, VIC 3083, Australia.
Chaitali DekiwadiaRMIT Microscopy & Microanalysis Facility, School of Science, RMIT University, Melbourne, VIC 3001, Australia.
Thi Thu Hao VanSchool of Science, RMIT University, 264 Plenty Road, Bundoora, VIC 3083, Australia.
Carina C D JoeCSIRO Manufacturing, Clayton, VIC 3169, Australia.
Tram PhanCSIRO Manufacturing, Clayton, VIC 3169, Australia.
George LovreczCSIRO Manufacturing, Clayton, VIC 3169, Australia.ORCID 0000-0001-9977-5065
Paul R GorryDepartment of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute of Infection and Immunity, Parkville, VIC 3010, Australia.
Paul A RamslandSchool of Science, RMIT University, 264 Plenty Road, Bundoora, VIC 3083, Australia.
Anna K WalduckSchool of Science, RMIT University, 264 Plenty Road, Bundoora, VIC 3083, Australia.ORCID 0000-0002-9624-4370
Peter M SmookerSchool of Science, RMIT University, 264 Plenty Road, Bundoora, VIC 3083, Australia.
RMIT University · AUCSIRO Manufacturing · AUThe University of Melbourne · AU

Funding

Cass Foundation # SM/14/5403/DSA:DRRMIT University # CDF17137
6 · The paper itself

Abstract

Nanoparticles show great promise as a platform for developing vaccines for the prevention of infectious disease. We have been investigating a method whereby nanocapsules can be formulated from protein, such that the final capsules contain only the cross-linked protein itself. Such nanocapsules are made using a silica templating system and can be customised in terms of size and porosity. Here we compare the construction and characteristics of nanocapsules from four different proteins: one a model protein (ovalbumin) and three from infectious disease pathogens, namely the influenza virus,

Indexed as

Helicobacter pyloriHIVinfluenza virusnanoparticlesvaccines

Identifiers

PMID38675791
PMCPMC11053559
OpenAlexW4394749050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.