Evidence map›Paper›PMID 38675769›Full record

ArticleVaccines2024

Characteristics and Outcomes for Recipients of NVX-CoV2373: A Real-World Retrospective Study in Germany.

Lucie Kutikova, James T Brash, Kawitha Helme, Jack Brewster, Milou Brand, Atif Adam, Sarah Seager, Karel Kostev, Jörg Schelling

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Lucie KutikovaNovavax Europe, 8001 Zurich, Switzerland.
James T BrashIQVIA, London W2 1AF, UK.
Kawitha HelmeNovavax Europe, 8001 Zurich, Switzerland.
Jack BrewsterIQVIA, London W2 1AF, UK.
Milou BrandIQVIA, London W2 1AF, UK.ORCID 0000-0002-1992-4751
Atif AdamIQVIA, London W2 1AF, UK.
Sarah SeagerIQVIA, London W2 1AF, UK.
Karel KostevIQVIA, Epidemiology, 60549 Frankfurt am Main, Germany.ORCID 0000-0002-2124-7227
Jörg SchellingDepartment of Medicine IV, Ludwig Maximilian University of Munich University Hospital, LMU Munich, 80336 Munich, Germany.ORCID 0000-0002-5872-2335
IQVIA (United Kingdom) · GBLudwig-Maximilians-Universität München · DE

Funding

Novavax Europe N/A
6 · The paper itself

Abstract

Real-world evidence supports SARS-CoV-2 vaccination strategies during the COVID-19 pandemic. This real-world retrospective study utilized the German Disease Analyzer database to characterize recipients of NVX-CoV2373 and explore vaccination outcomes. Recipients (≥12 years) of NVX-CoV2373 as a primary series or booster in Germany were vaccinated between March and December 2022. Outcomes included demographics and clinical characteristics of recipients, tolerability/reactogenicity-related events within 7 and 14 days post-vaccination, and protection from COVID-19. Overall, there were 597 recipients (mean age ~60 years) of NVX-CoV2373; 81% were vaccinated by a general practitioner, and 68% had a Standing Committee on Vaccination (STIKO) high-risk factor. The most common baseline comorbidities were chronic neurological (36%) and chronic intestinal (21%) diseases. Among recipients with metabolic disease (~11%), 65% had diabetes. Tolerability/reactogenicity-related symptoms were recorded in ~1% of recipients. There were no sick-leave notes associated with NVX-CoV2373. After 10 months (median, 7 months) of follow-up, 95% (95% CI, 93-95) of recipients were estimated to be protected from COVID-19. Outcomes were similar across the primary series, booster, and STIKO populations. Tolerability and COVID-19 protection support the use of NVX-CoV2373 as a primary/booster vaccination for all authorized populations, including high-risk.

Indexed as

COVID-19duration of protectioneffectivenessGermanyNVX-CoV2373outcomespractical vaccinationreactogenicityreal-world evidence

Identifiers

PMID38675769
PMCPMC11054037
OpenAlexW4394579906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.