Evidence map›Paper›PMID 38675760›Full record

ArticleVaccines2024

Diphtheria and Tetanus Immunity Status among Greek Adults: Results from a Nationwide Seroprevalence Study.

Dimitrios Papagiannis, Eleftherios Thireos, Anargiros Mariolis, Antonios Katsioulis, Ioannis Ch Lampropoulos, Ioanna Tsiaousi, Kostantina Gartzonika, Niki Malliaraki, Foteini Malli, Erasmia C Rouka and 4 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Dimitrios PapagiannisPublic Health & Vaccines Laboratory, Faculty of Nursing, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece.ORCID 0000-0001-6123-559X
Eleftherios ThireosNational Health System of Greece, Primary Health Center of Vari, 16672 Athens, Greece.
Anargiros MariolisNational Health System of Greece, Primary Health Center, 23062 Areopolis, Greece.
Antonios KatsioulisPublic Health & Vaccines Laboratory, Faculty of Nursing, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece.
Ioannis Ch LampropoulosRespiratory Disorders Lab, Faculty of Nursing, University of Thessaly, 41110 Larissa, Greece.ORCID 0000-0002-8956-2178
Ioanna TsiaousiPrivate Primary Health Sector, Queen Sophia Avenue 123, 11521 Athens, Greece.
Kostantina GartzonikaMicrobiology Department, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Niki MalliarakiLaboratory of Clinical Chemistry-Biochemistry, University Hospital of Heraklion, 71003 Crete, Greece.
Foteini MalliRespiratory Disorders Lab, Faculty of Nursing, University of Thessaly, 41110 Larissa, Greece.ORCID 0000-0002-7595-6715
Erasmia C RoukaPublic Health & Vaccines Laboratory, Faculty of Nursing, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece.ORCID 0000-0003-2885-4510
Georgios MarinosDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-2280-8361
Emmanouil K SymvoulakisDepartment of Social Medicine, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.
Georgios RachiotisDepartment of Hygiene and Epidemiology, Medical Faculty, School of Health Science, University of Thessaly, 42200 Larissa, Greece.
Konstantinos I GourgoulianisDepartment of Respiratory Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, BIOPOLIS, 41110 Larissa, Greece.ORCID 0000-0001-9541-1010
University of Thessaly · GRNational School of Public Health · GRNational and Kapodistrian University of Athens · GRUniversity Hospital of Heraklion · GRUniversity of Crete · GRUniversity of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diphtheria and tetanus could lead to serious morbidity. We aimed to evaluate immunity levels by measuring specific IgG antibodies for diphtheria and tetanus in serum samples from a nationally expanded sample of the Greek population. A geographically stratified sampling approach based on regional units (NUTS level 2) was applied by considering variables such as age group (30-80+) and sex. In total, 1201 persons (47.7% males and 52.3% females) participated in the survey. Bivariate analysis revealed a negative relationship between diphtheria and tetanus median antibody titers and age. The overall seropositivity rate for diphtheria IgG antibodies (≥0.10 IU/mL) was estimated at 31.5%. Regarding tetanus, the total seropositivity rate was estimated at 59.5% (tetanus IgG antibodies ≥0.10 IU/mL). Logistic regression analysis indicated that age groups <40 years and 40-59 years were independently associated with tetanus seropositivity. Logistic regression also revealed that male sex and being aged 60-69 years were independent risk factors for diphtheria-related seropositivity. Lastly, being resident of some regions was an independent risk factor for both diphtheria- and tetanus-related seropositivity. The present study shows that Greek adults are still not completely immune to diphtheria and tetanus. It is likely possible to achieve optimal immunization coverage by implementing serviceable public health initiatives after comprehending real community needs.

Indexed as

booster vaccinationsdiphtheriaimmunity statustetanusvaccines

Identifiers

PMID38675760
PMCPMC11055123
OpenAlexW4393538707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.