Evidence map›Paper›PMID 38675640›Full record

ArticleMolecules (Basel, Switzerland)2024

The Synthesis of 2'-Hydroxychalcones under Ball Mill Conditions and Their Biological Activities.

Imen Abid, Wassim Moslah, Sandrine Cojean, Nicolas Imbert, Philippe M Loiseau, Alain Chamayou, Najet Srairi-Abid, Rachel Calvet, Michel Baltas

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Imen AbidLCC (Laboratoire de Chimie de Coordination), UPR CNRS 8241, Université de Toulouse, UPS, INPT, Inserm ERL 1289, 205 Route de Narbonne, BP 44099, CEDEX 4, F-31077 Toulouse, France.
Wassim MoslahLaboratoire des Biomolecules, Venins et Applications Théranostiques (LR20IPT01), Institut Pasteur de Tunis, Université Tunis-ElManar, Tunis 1002, Tunisia.
Sandrine CojeanBioCIS (Biomolécules: Conception, Isolement et Synthèse), UMR CNRS 8076, Université Paris-Saclay, F-91400 Orsay, France.
Nicolas ImbertBioCIS (Biomolécules: Conception, Isolement et Synthèse), UMR CNRS 8076, Université Paris-Saclay, F-91400 Orsay, France.
Philippe M LoiseauBioCIS (Biomolécules: Conception, Isolement et Synthèse), UMR CNRS 8076, Université Paris-Saclay, F-91400 Orsay, France.ORCID 0000-0002-8542-6793
Alain ChamayouCentre RAPSODEE (Recherche d'Albi en génie des Procédés des SOlides Divisés, de l'Energie et de l'Environnement), IMT Mines Albi, UMR CNRS 5302, Université de Toulouse, Campus Jarlard, Allée des Sciences, CEDEX 09, F-81013 Albi, France.ORCID 0000-0002-2060-1837
Najet Srairi-AbidLaboratoire des Biomolecules, Venins et Applications Théranostiques (LR20IPT01), Institut Pasteur de Tunis, Université Tunis-ElManar, Tunis 1002, Tunisia.
Rachel CalvetCentre RAPSODEE (Recherche d'Albi en génie des Procédés des SOlides Divisés, de l'Energie et de l'Environnement), IMT Mines Albi, UMR CNRS 5302, Université de Toulouse, Campus Jarlard, Allée des Sciences, CEDEX 09, F-81013 Albi, France.
Michel BaltasLCC (Laboratoire de Chimie de Coordination), UPR CNRS 8241, Université de Toulouse, UPS, INPT, Inserm ERL 1289, 205 Route de Narbonne, BP 44099, CEDEX 4, F-31077 Toulouse, France.ORCID 0000-0002-8785-7095

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chalcones are polyphenols that belong to the flavonoids family, known for their broad pharmacological properties. They have thus attracted the attention of chemists for their obtention and potential activities. In our study, a library of compounds from 2'-hydroxychalcone's family was first synthesized. A one-step mechanochemical synthesis via Claisen-Schmidt condensation reaction under ball mill conditions was studied, first in a model reaction between a 5'-fluoro-2'-hydroxyacetophenone and 3,4-dimethoxybenzaldehyde. The reaction was optimized in terms of catalysts, ratio of reagents, reaction time, and influence of additives. Among all assays, we retained the best one, which gave the highest yield of 96% when operating in the presence of 1 + 1 eq. of substituted benzaldehyde and 2 eq. of KOH under two grinding cycles of 30 min. Thus, this protocol was adopted for the synthesis of the selected library of 2'-hydroxychalcones derivatives. The biological activities of 17 compounds were then assessed against

Indexed as

ChalconesPlasmodium falciparumAntimalarialsAntineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalHumansLeishmania donovaniMolecular Structure2'-hydroxychalconeAntimalarialsAntineoplastic AgentsChalconesantiparasiticantitumoralball mill mechanochemistrychalconesphenolicssustainable synthesis

Identifiers

PMID38675640
PMCPMC11054009

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.