Evidence map›Paper›PMID 38675608›Full record

ArticleMolecules (Basel, Switzerland)2024

Artemisinin Confers Cytoprotection toward Hydrogen Peroxide-Induced Cell Apoptosis in Retinal Pigment Epithelial Cells in Correlation with the Increased Acetylation of Histone H4 at Lysine 8.

Chao Yang, Lijun Ge, Xiyong Yu, Philip Lazarovici, Wenhua Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Chao YangDepartment of Pharmaceutical Science, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau, China.
Lijun GeDepartment of Pharmaceutical Science, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau, China.
Xiyong YuSchool of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
Philip LazaroviciSchool of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.ORCID 0000-0003-3650-4721
Wenhua ZhengDepartment of Pharmaceutical Science, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau, China.
University of Macau · MOGuangzhou Medical University · CNHebrew University of Jerusalem · ILZhejiang Chinese Medical University · CN

Funding

Guangdong Provincial Funding Committee for Basic and Applied Fundamental Research 2022-Natural Science FoundationNational Natural Science Foundation of China 31771128 and 31371088Science and Technology Development Fund 0127/2019/A3, 0113/2018/A3, 0038/2020/AMJ, and 0104/2022/A2University of Macau MYRG2018-00134-FHS and MYRG2020-00158-FHS
6 · The paper itself

Abstract

Increased oxidative stress is one of the critical pathologies inducing age-related macular degeneration (AMD), characterized by retinal pigment epithelial (RPE) cell damage and death. The unbalanced acetylation and deacetylation of histones have been implicated in AMD pathogenesis or hydrogen peroxide (H

Indexed as

ApoptosisArtemisininsCell SurvivalHistonesHydrogen PeroxideLysineOxidative StressRetinal Pigment EpitheliumAcetylationCell LineCytoprotectionEpithelial CellsHumansartemisininArtemisininsHistonesHydrogen PeroxideLysineAcetyl-H4 (Lys 8)apoptosisArtemisinincytoprotectionH2O2retinal pigment epithelial cells

Identifiers

PMID38675608
PMCPMC11051841
OpenAlexW4394809689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.