Rapid Apta-Chromogenic Detection Method for Nitrofuran Metabolite Determination.

Navarat Chaisri, Chutikarn Jaengphop, Ikuo Hirono, Sasimanas Unajak

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.7field-weighted citation impact, top 32% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

A sensitive and accurate method for determination of nitrofurans metabolites in food samples by ultra-high performance liquid chromatography-tandem mass spectrometry with a pair of facile isotope-coded derivatization reagents.Analytical and bioanalytical chemistry · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Navarat ChaisriInterdisciplinary Graduate Program in Genetic Engineering, The Graduate School, Kasetsart University, Bangkok 10900, Thailand.

Chutikarn JaengphopDepartment of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.

Ikuo HironoLaboratory of Genome Science, Graduate School of Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan.

Sasimanas UnajakInterdisciplinary Graduate Program in Genetic Engineering, The Graduate School, Kasetsart University, Bangkok 10900, Thailand.ORCID 0000-0002-3242-3978

Kasetsart University · THTokyo University of Marine Science and Technology · JP

Funding

Japan Science and Technology Agency/Japan International Cooperation Agency, Science and Technology Research Partnership for Sustainable Development (JST/JICA, SATREPS)Kasetsart University Research and Development Institute KURDI FF(KU) 17.64Kasetsart University through the Graduate School Fellowship Program Navarat Chaisri

6 · The paper itself

Abstract

Nitrofuran (NF) contamination in food products is a global problem resulting in the banned utilization and importation of nitrofuran contaminated products. A novel chromogenic detection method using a specific DNA aptamer with high affinity and specificity to nitrofurans was developed. Single-stranded DNA aptamers specific to nitrofuran metabolites, including 3-amino-2-oxazolidinone (AOZ), 3-amino-5-methylmorpholino-2-oxazolidinone (AMOZ), and 1-aminohydantoin (AHD), were isolated using magnetic bead-SELEX. The colorimetric detection of nitrofurans using gold nanoparticles (AuNPs) exhibited an AOZ detection range of 0.01-0.06 ppb with a limit of detection (LOD) of 0.03 ppb. At the same time, this system could detect AMOZ and AHD at a range of 0.06 ppb and 10 ppb, respectively. The fast nitrofuran extraction method was optimized for food, such as fish tissues and honey, adjusted to be completed within 3-6 h. This novel apta-chromogenic detection method could detect NF metabolites with a sensitivity below the minimum required performance limit (MPRL). This analysis will be valuable for screening, with a shortened time of detection for aquaculture products such as shrimp and fish muscle tissues.

Indexed as

Aptamers, NucleotideFood ContaminationMetal NanoparticlesNitrofuransAnimalsColorimetryFood AnalysisGoldHoneyHydantoinsLimit of DetectionOxazolidinones1-aminohydantoin3-amino-2-oxazolidinoneAptamers, NucleotideGoldHydantoinsNitrofuransOxazolidinonesapta-chromogenic detectionaptamercolorimetric detectiondetectionnitrofuran metabolitessimultaneous detection

Identifiers

PMID38675539

DOI10.3390/molecules29081720

PMCPMC11052085

OpenAlexW4394725191

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.