Evidence map›Paper›PMID 38675537›Full record

ArticleMolecules (Basel, Switzerland)2024

Screening and Application of DNA Aptamers for Heparin-Binding Protein.

Xi Zhou, Yingying Cao, Xiaocui Huang, Shuqian Qiu, Xinran Xiang, Huimin Niu, Li Chen, Shuiliang Wang, Zhenyu Lin, Shenghang Zhang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xi ZhouFujian Key Laboratory of Aptamers Technology, Fuzhou General Teaching Hospital (the 900th Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou 350025, China.ORCID 0009-0008-2499-5918
Yingying CaoFujian Key Laboratory of Aptamers Technology, Fuzhou General Teaching Hospital (the 900th Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou 350025, China.ORCID 0009-0004-2090-8064
Xiaocui HuangDepartment of Science Research and Training, Fujian Institute of Education, Fuzhou 350001, China.
Shuqian QiuFujian Key Laboratory of Aptamers Technology, Fuzhou General Teaching Hospital (the 900th Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou 350025, China.
Xinran XiangFujian Key Laboratory of Aptamers Technology, Fuzhou General Teaching Hospital (the 900th Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou 350025, China.ORCID 0000-0002-2574-7333
Huimin NiuFujian Key Laboratory of Aptamers Technology, Fuzhou General Teaching Hospital (the 900th Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou 350025, China.
Li ChenFujian Key Laboratory of Aptamers Technology, Fuzhou General Teaching Hospital (the 900th Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou 350025, China.
Shuiliang WangFujian Key Laboratory of Aptamers Technology, Fuzhou General Teaching Hospital (the 900th Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou 350025, China.ORCID 0000-0002-5054-9064
Zhenyu LinMOE Key Laboratory of Analysis and Detection for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350116, China.ORCID 0000-0001-7890-6812
Shenghang ZhangFujian Key Laboratory of Aptamers Technology, Fuzhou General Teaching Hospital (the 900th Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou 350025, China.ORCID 0000-0003-1602-7681
Fujian University of Traditional Chinese Medicine · CNFujian Institute of Education · CNFuzhou University · CN

Funding

900th Hospital of Joint Logistics Support Force 2021ZD05900th Hospital of Joint Logistics Support Force 2023XKJY01Cooperative Project with Foreign Investigator, Natural Science Foundation of Fujian Province of China 2023I0029Fujian Clinical Research Center for Aptamer-based Precision Testing 2021Y2017
6 · The paper itself

Abstract

Rapid detection of heparin-binding protein (HBP) is essential for timely intervention in sepsis cases. Current detection techniques are usually antibody-based immunological methods, which have certain problems, such as complexity and slow detection, and fall short in meeting the urgency of clinical needs. The application of an aptamer can address these concerns well. In this study, HBP-specific DNA aptamers were screened first. Among which, Apt-01, Apt-02, and Apt-13 had a high affinity for HBP, exhibiting impressive K

Indexed as

Antimicrobial Cationic PeptidesAptamers, NucleotideBiosensing TechniquesBlood ProteinsDNAHumansLimit of DetectionAntimicrobial Cationic PeptidesAptamers, NucleotideAZU1 protein, humanBlood ProteinsDNAaptamersbiosensorsheparin-binding proteinrolling circle amplificationsepsis

Identifiers

PMID38675537
PMCPMC11051826
OpenAlexW4394687391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.