Iodine-Catalyzed Cascade Annulation of 4-Hydroxycoumarins with Aurones: Access to Spirocyclic Benzofuran-Furocoumarins.

Xuequan Wang, Changhui Yang, Dan Yue, Mingde Xu, Suyue Duan, Xianfu Shen

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Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

A concise synthesis of pyrrolo[2,3-d]pyrimidine through IBMC chemistry · 2025
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Authors and funding

6 authors.

Xuequan WangSchool of Chemistry and Resources Engineering, Honghe University, Honghe 661100, China.ORCID 0000-0001-8880-7412

Changhui YangSchool of Chemistry and Resources Engineering, Honghe University, Honghe 661100, China.

Dan YueSchool of Chemistry and Resources Engineering, Honghe University, Honghe 661100, China.

Mingde XuSchool of Chemistry and Resources Engineering, Honghe University, Honghe 661100, China.

Suyue DuanSchool of Chemistry and Resources Engineering, Honghe University, Honghe 661100, China.

Xianfu ShenCollege of Chemistry and Environmental Science, Qujing Normal University, Qujing 655011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An attractive approach for the preparation of spirocyclic benzofuran-furocoumarins has been developed through iodine-catalyzed cascade annulation of 4-hydroxycoumarins with aurones. The reaction involves Michael addition, iodination, and intramolecular nucleophilic substitution in a one-step process, and offers an efficient method for easy access to a series of valuable spirocyclic benzofuran-furocoumarins in good yields (up to 99%) with excellent stereoselectivity. Moreover, this unprecedented protocol provides several advantages, including readily available materials, an environmentally benign catalyst, a broad substrate scope, and a simple procedure.

Indexed as

benzofuranfurocoumariniodine-catalyzed cascade annulationspiro-heterocycle

Identifiers

PMID38675521

DOI10.3390/molecules29081701

PMCPMC11052457

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