Evidence map›Paper›PMID 38675501›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

A Holographic-Type Model in the Description of Polymer-Drug Delivery Processes.

Irina Nica, Constantin Volovat, Diana Boboc, Ovidiu Popa, Lacramioara Ochiuz, Decebal Vasincu, Vlad Ghizdovat, Maricel Agop, Cristian Constantin Volovat, Corina Lupascu Ursulescu and 2 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Irina NicaDepartment of Odontology-Periodontology, Fixed Prosthesis, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0003-1189-0785
Constantin VolovatDepartment of Medical Oncology-Radiotherapy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Str, 700115 Iasi, Romania.ORCID 0000-0003-1582-0135
Diana BobocDepartment of Medical Oncology-Radiotherapy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Str, 700115 Iasi, Romania.
Ovidiu PopaDepartment of Emergency Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0001-9434-1751
Lacramioara OchiuzFaculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0001-6447-0958
Decebal VasincuDepartment of Biophysics, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-7139-0304
Vlad GhizdovatDepartment of Biophysics and Medical Physics, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Maricel AgopDepartment of Physics, "Gheorghe Asachi" Technical University of Iasi, 700050 Iasi, Romania.
Cristian Constantin VolovatDepartment of Radiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Corina Lupascu UrsulescuDepartment of Radiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-7539-9453
Cristian Virgil LungulescuDepartment of Oncology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Simona Ruxandra VolovatDepartment of Medical Oncology-Radiotherapy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Str, 700115 Iasi, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A unitary model of drug release dynamics is proposed, assuming that the polymer-drug system can be assimilated into a multifractal mathematical object. Then, we made a description of drug release dynamics that implies, via Scale Relativity Theory, the functionality of continuous and undifferentiable curves (fractal or multifractal curves), possibly leading to holographic-like behaviors. At such a conjuncture, the Schrödinger and Madelung multifractal scenarios become compatible: in the Schrödinger multifractal scenario, various modes of drug release can be "mimicked" (via period doubling, damped oscillations, modulated and "chaotic" regimes), while the Madelung multifractal scenario involves multifractal diffusion laws (Fickian and non-Fickian diffusions). In conclusion, we propose a unitary model for describing release dynamics in polymer-drug systems. In the model proposed, the polymer-drug dynamics can be described by employing the Scale Relativity Theory in the monofractal case or also in the multifractal one.

Indexed as

drug deliveryfractal/multifractal curvesmultifractal diffusion lawsnanomedicineSchrödinger and Madelung scenarios

Identifiers

PMID38675501
PMCPMC11053585

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.