Evidence map›Paper›PMID 38675488›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation.

Jiayi Huang, Shiqi Hong, Lucas Yuan Hao Goh, Hailong Zhang, Tao Peng, Keat Theng Chow, Rajeev Gokhale, Vinod Tuliani

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiayi HuangPharma Applied Sciences, Roquette Asia Pacific Pte Ltd., Singapore 138588, Singapore.ORCID 0000-0002-5222-4060
Shiqi HongPharma Applied Sciences, Roquette Asia Pacific Pte Ltd., Singapore 138588, Singapore.
Lucas Yuan Hao GohPharma Applied Sciences, Roquette Asia Pacific Pte Ltd., Singapore 138588, Singapore.
Hailong ZhangPharma Applied Sciences, Roquette Asia Pacific Pte Ltd., Singapore 138588, Singapore.
Tao PengPharma Applied Sciences, Roquette Asia Pacific Pte Ltd., Singapore 138588, Singapore.
Keat Theng ChowPharma Applied Sciences, Roquette Asia Pacific Pte Ltd., Singapore 138588, Singapore.
Rajeev GokhaleGlobal Pharmaceutical Sciences, Roquette America Inc., 2211 Innovation Drive, Geneva, IL 60134, USA.
Vinod TulianiRoquette Pharmaceutical Innovation Center, Lower Gwynedd Township, PA 19002, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE

Indexed as

bevacizumabexcipienthydroxypropyl beta-cyclodextrinipilimumabKLEPTOSE® HPβCDmonoclonal antibodypolysorbateprotein formulationprotein stability

Identifiers

PMID38675488
PMCPMC11054243
OpenAlexW4394963278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.