Evidence map›Paper›PMID 38675448›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Bioactive Properties of Venoms Isolated from Whiptail Stingrays and the Search for Molecular Mechanisms and Targets.

Craig A Doupnik, Carl A Luer, Catherine J Walsh, Jessica Restivo, Jacqueline Xinlan Brick

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Craig A DoupnikDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-7314-0747
Carl A LuerMarine Biomedical Research Program, Mote Marine Laboratory, Sarasota, FL 34236, USA.
Catherine J WalshMarine Immunology Program, Mote Marine Laboratory, Sarasota, FL 34236, USA.ORCID 0000-0002-8279-5542
Jessica RestivoMarine Immunology Program, Mote Marine Laboratory, Sarasota, FL 34236, USA.
Jacqueline Xinlan BrickDepartment of Biology, College of Arts & Sciences, Oberlin College and Conservatory, Oberlin, OH 44074, USA.ORCID 0009-0006-1220-4934
Mote Marine Laboratory · USOberlin College · USUniversity of South Florida · US

Funding

National Science Foundation OCE-2050892
6 · The paper itself

Abstract

The venom-containing barb attached to their 'whip-like' tail provides stingrays a defensive mechanism for evading predators such as sharks. From human encounters, dermal stingray envenomation is characterized by intense pain often followed by tissue necrosis occurring over several days to weeks. The bioactive components in stingray venoms (SRVs) and their molecular targets and mechanisms that mediate these complex responses are not well understood. Given the utility of venom-derived proteins from other venomous species for biomedical and pharmaceutical applications, we set out to characterize the bioactivity of SRV extracts from three local species that belong to the

Indexed as

apoptosiscell adhesioncell growthfibrosarcomagalectin-like proteinsnecrosisstingraytoxinvenom

Identifiers

PMID38675448
PMCPMC11053709
OpenAlexW4394726379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.