Evidence map›Paper›PMID 38675447›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Dual Antitubercular and Antileishmanial Profiles of Quinoxaline Di-

Juan F González, María-Auxiliadora Dea-Ayuela, Lena Huck, José María Orduña, Francisco Bolás-Fernández, Elena de la Cuesta, Nazia Haseen, Ashraf Ali Mohammed, J Carlos Menéndez

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Juan F GonzálezUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.ORCID 0000-0002-4568-7200
María-Auxiliadora Dea-AyuelaDepartamento de Farmacia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, c/Santiago Ramón y Cajal, Alfara del Patriarca, 46115 Valencia, Spain.ORCID 0000-0002-5468-1863
Lena HuckUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.
José María OrduñaUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.ORCID 0000-0003-4955-4998
Francisco Bolás-FernándezDepartamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.
Elena de la CuestaUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.
Nazia HaseenAMIPRO SDN.BHD. Level 3, Bangunan Inkubator Universiti, Sains@USM, Lebuh Bukit Jambul, Bayan Lepas 11900, Pulau Pinang, Malaysia.
Ashraf Ali MohammedAMIPRO SDN.BHD. Level 3, Bangunan Inkubator Universiti, Sains@USM, Lebuh Bukit Jambul, Bayan Lepas 11900, Pulau Pinang, Malaysia.
J Carlos MenéndezUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.ORCID 0000-0002-0560-8416
Universidad Complutense de Madrid · ESUniversiti Sains Malaysia · MYUniversidad Cardenal Herrera CEU · ES

Funding

Ministerio de Ciencia e Innovación TED2021-129408B-I00
6 · The paper itself

Abstract

We present a new category of quinoxaline di-N-oxides (QdNOs) containing amino acid side chains with dual antituberculosis and antileishmanial activity. These compounds were synthesized by combining a regioselective 2,5-piperazinedione opening and a Beirut reaction and were screened for their activity against

Indexed as

antileishmanialantitubercularco-infectionsdrug designneglected tropical diseasesN-oxidesstructure–activity relationships

Identifiers

PMID38675447
PMCPMC11054274
OpenAlexW4394726633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.