ArticlePharmaceuticals (Basel, Switzerland)2024
Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta.
Sara Calenda, Daniela Catarzi, Flavia Varano, Erica Vigiani, Rosaria Volpini, Catia Lambertucci, Andrea Spinaci, Letizia Trevisan, Ilenia Grieco, Stephanie Federico and 5 more
Open access · goldAbstract read
In one paragraphArticle in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors at 4 institutions in 1 country.
Sara CalendaSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Via Ugo Schiff, 6, 50019 Florence, Italy.
Daniela CatarziSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Via Ugo Schiff, 6, 50019 Florence, Italy.ORCID 0000-0002-8821-928X Flavia VaranoSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Via Ugo Schiff, 6, 50019 Florence, Italy.
Erica VigianiSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Via Ugo Schiff, 6, 50019 Florence, Italy.
Rosaria VolpiniMedicinal Chemistry Unit, School of Pharmacy, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy.ORCID 0000-0002-5304-5232 Catia LambertucciMedicinal Chemistry Unit, School of Pharmacy, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy.ORCID 0000-0003-2004-1531 Andrea SpinaciMedicinal Chemistry Unit, School of Pharmacy, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy.ORCID 0000-0002-5172-651X Letizia TrevisanDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via Licio Giorgieri 1, 34127 Trieste, Italy.ORCID 0009-0007-2858-8482 Ilenia GriecoDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via Licio Giorgieri 1, 34127 Trieste, Italy.
Stephanie FedericoDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via Licio Giorgieri 1, 34127 Trieste, Italy.ORCID 0000-0003-2800-5287 Giampiero SpallutoDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via Licio Giorgieri 1, 34127 Trieste, Italy.ORCID 0000-0002-1957-7155 Gianluca NovelloMolecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.
Veronica SalmasoMolecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.
Stefano MoroMolecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.ORCID 0000-0002-7514-3802 Vittoria ColottaSection of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Via Ugo Schiff, 6, 50019 Florence, Italy.ORCID 0000-0002-9296-6819 University of Florence · ITUniversity of Trieste · ITUniversità di Camerino · ITUniversity of Padua · IT
Funding
Italian Ministry of University and Research-PRIN2017 2017MT3993_004University of Florence RICATEN2021-2023Colotta
6 · The paper itselfAbstract
Protein kinase CK1δ (CK1δ) is a serine-threonine/kinase that modulates different physiological processes, including the cell cycle, DNA repair, and apoptosis. CK1δ overexpression, and the consequent hyperphosphorylation of specific proteins, can lead to sleep disorders, cancer, and neurodegenerative diseases. CK1δ inhibitors showed anticancer properties as well as neuroprotective effects in cellular and animal models of Parkinson's and Alzheimer's diseases and amyotrophic lateral sclerosis. To obtain new ATP-competitive CK1δ inhibitors, three sets of benzimidazole-2-amino derivatives were synthesized (
Indexed as
benzimidazole derivativesCK1δ inhibitorsmolecular modeling
Identifiers
PMID38675428
PMCPMC11054282
OpenAlexW4394579651
What OpenQuestion holds
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LicenceCC BY
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