Evidence map›Paper›PMID 38675389›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Identification of Ureidocoumarin-Based Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors via Drug Repurposing Approach, Biological Evaluation, and In Silico Studies.

Ashraf K El-Damasy, Hyun Ji Kim, Ahmed A Al-Karmalawy, Radwan Alnajjar, Mohamed M Khalifa, Eun-Kyoung Bang, Gyochang Keum

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Ashraf K El-DamasyBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.ORCID 0000-0002-8446-0383
Hyun Ji KimBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Ahmed A Al-KarmalawyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt.ORCID 0000-0002-8173-6073
Radwan AlnajjarCADD Unit, Faculty of Pharmacy, Libyan International Medical University, Benghazi 16063, Libya.ORCID 0000-0003-1869-9596
Mohamed M KhalifaDepartment of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.ORCID 0000-0002-8146-993X
Eun-Kyoung BangBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Gyochang KeumBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.ORCID 0000-0001-8767-8022
Korea Institute of Brain Science · KRAl-Azhar University · EGDamietta University · EGMansoura University · EGUniversity of Cape Town · ZA

Funding

Korea Institute of Science and Technology 2E32212National Research Foundation of Korea NRF-2019H1D3A1A01070882 and NRF-2021M3E5E3080563
6 · The paper itself

Abstract

Discoidin domain receptor 1 (DDR1) kinase has emerged as a promising target for cancer therapy, and selective DDR1 inhibitors have shown promise as effective therapeutic candidates. Herein, we have identified the first coumarin-based selective DDR1 inhibitors via repurposing of a recent series of carbonic anhydrase inhibitors. Among these, ureidocoumarins

Indexed as

antiproliferative activityDDR1/2 kinasesdrug repurposingMD simulationsmolecular dockingureidocoumarin

Identifiers

PMID38675389
PMCPMC11054573
OpenAlexW4393218356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.