Evidence map›Paper›PMID 38675387›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Trichostatin C Synergistically Interacts with DNMT Inhibitor to Induce Antineoplastic Effect via Inhibition of Axl in Bladder and Lung Cancer Cells.

Chenyin Wang, Lijuan Lei, Yang Xu, Yan Li, Jing Zhang, Yanni Xu, Shuyi Si

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chenyin WangNHC Key Laboratory of Biotechnology of Antibiotics, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing 100050, China.ORCID 0000-0002-4963-777X
Lijuan LeiNHC Key Laboratory of Biotechnology of Antibiotics, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing 100050, China.
Yang XuNHC Key Laboratory of Biotechnology of Antibiotics, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing 100050, China.
Yan LiNHC Key Laboratory of Biotechnology of Antibiotics, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing 100050, China.
Jing ZhangNHC Key Laboratory of Biotechnology of Antibiotics, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing 100050, China.
Yanni XuNHC Key Laboratory of Biotechnology of Antibiotics, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing 100050, China.
Shuyi SiNHC Key Laboratory of Biotechnology of Antibiotics, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing 100050, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Chinese Academy of Medical Sciences & Peking Union Medical College CAMS Innovation fund for Medical Sciences (2021-I2M-1-054)Ministry of Science and Technology of the People's Republic of China National Key R&D Program of China (No. 2022YFC2804700)National Natural Science Foundation of China 42206112
6 · The paper itself

Abstract

Aberrant epigenetic modifications are fundamental contributors to the pathogenesis of various cancers. Consequently, targeting these aberrations with small molecules, such as histone deacetylase (HDAC) inhibitors and DNA methyltransferase (DNMT) inhibitors, presents a viable strategy for cancer therapy. The objective of this study is to assess the anti-cancer efficacy of trichostatin C (TSC), an analogue of trichostatin A sourced from the fermentation of

Indexed as

AxlcancerDNA methyltransferase inhibitordrug combination studyhistone deacetylase inhibitornatural product

Identifiers

PMID38675387
PMCPMC11053535
OpenAlexW4393235405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.