Evidence map›Paper›PMID 38675353›Full record

ArticleMicromachines2024

Precision Phenotypic Profiling and Capture of Circulating Tumor Cells via a Vertical Laminar Flow-Stacked Microfluidic Chip.

Xinping Zhang, Yuan Ma, Yujiao Wang, Zhenwei Liang, Xuanhe Zhang, Yiqing Chen, Qingyi Wang, Hua Qin, Jiadao Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xinping ZhangSchool of Mechanical-Electronic and Vehicle Engineering, Beijing University of Civil Engineering and Architecture, Beijing 102616, China.
Yuan MaDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-3595-2450
Yujiao WangDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Zhenwei LiangDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Xuanhe ZhangDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Yiqing ChenDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Qingyi WangSchool of Mechanical-Electronic and Vehicle Engineering, Beijing University of Civil Engineering and Architecture, Beijing 102616, China.
Hua QinSchool of Mechanical-Electronic and Vehicle Engineering, Beijing University of Civil Engineering and Architecture, Beijing 102616, China.
Jiadao WangDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Tsinghua University · CNBeijing University of Civil Engineering and Architecture · CN

Funding

National Natural Science Foundation of China 52205312National Natural Science Foundation of China 52275200
6 · The paper itself

Abstract

The heterogeneity of circulating tumor cells has a significant impact on the diagnosis, treatment, and monitoring of cancer. Research on the subtypes of circulating tumor cells can bring better treatment outcomes for cancer patients. Here, we proposed a microfluidic chip for the magnetic capture of subtypes of circulating tumor cells from the whole blood and phenotypic profiling by stacking laminar flow vertically. Circulating tumor cells were sorted and captured by the three-dimensional regulation of both magnetic fields in the vertical direction and flow fields in the lateral direction. Using EpCAM-magnetic beads, we achieved sorting and sectional capture of target cells in whole blood and analyzed the surface expression levels of the captured cells, confirming the functionality of the microfluidic chip in sorting and capturing subtypes of circulating tumor cells. This microfluidic chip can also aid in the subsequent subtype analysis of other rare cells.

Indexed as

circulating tumor cellsmagnetic cell sortingmicrofluidic chipsubtype sorting

Identifiers

PMID38675353
PMCPMC11051858
OpenAlexW4394918593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.