Evidence map›Paper›PMID 38675225›Full record

ArticlePharmaceutics2024

Exploring the Impact of Hepatic Impairment on Pralsetinib Pharmacokinetics.

Kit Wun Kathy Cheung, Yang Tang, Doreen Anders, Teresa Barata, Astrid Scalori, Priya Agarwal, Rucha Sane, Sravanthi Cheeti

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Kit Wun Kathy CheungClinical Pharmacology, Genentech, Inc., South San Francisco, CA 94080, USA.
Yang TangDrug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA 94080, USA.
Doreen AndersClinical Safety, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland.
Teresa BarataData and Statistical Science, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland.
Astrid ScaloriClinical Development Oncology, F. Hoffmann-La Roche Ltd., Welwyn Garden City AL7 1TW, UK.
Priya AgarwalClinical Pharmacology, Genentech, Inc., South San Francisco, CA 94080, USA.
Rucha SaneClinical Pharmacology, Genentech, Inc., South San Francisco, CA 94080, USA.
Sravanthi CheetiClinical Pharmacology, Genentech, Inc., South San Francisco, CA 94080, USA.
Sunesis (United States) · USRoche (Switzerland) · CHRoche (United Kingdom) · GB

Funding

Genentech NA
6 · The paper itself

Abstract

Pralsetinib is a kinase inhibitor indicated for the treatment of metastatic rearranged during transfection (

Indexed as

hepatic impairmentpharmacokineticspralsetinib

Identifiers

PMID38675225
PMCPMC11053887
OpenAlexW4395011252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.