Evidence map›Paper›PMID 38675169›Full record

ArticlePharmaceutics2024

Effect of Micromixer Design on Lipid Nanocarriers Manufacturing for the Delivery of Proteins and Nucleic Acids.

Enrica Chiesa, Alessandro Caimi, Marco Bellotti, Alessia Giglio, Bice Conti, Rossella Dorati, Ferdinando Auricchio, Ida Genta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. New 3D Spiral Microfluidic Platform Tested for FeMolecules (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Enrica ChiesaDepartment of Drug Sciences, University of Pavia, V.le Taramelli 12, 27100 Pavia, Italy.
Alessandro CaimiDepartment of Civil Engineering and Architecture, University of Pavia, Via Ferrata 3, 27100 Pavia, Italy.ORCID 0000-0003-2856-1347
Marco BellottiDepartment of Civil Engineering and Architecture, University of Pavia, Via Ferrata 3, 27100 Pavia, Italy.
Alessia GiglioDepartment of Drug Sciences, University of Pavia, V.le Taramelli 12, 27100 Pavia, Italy.
Bice ContiDepartment of Drug Sciences, University of Pavia, V.le Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-0034-2815
Rossella DoratiDepartment of Drug Sciences, University of Pavia, V.le Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0001-5774-9547
Ferdinando AuricchioDepartment of Civil Engineering and Architecture, University of Pavia, Via Ferrata 3, 27100 Pavia, Italy.ORCID 0000-0002-3735-2400
Ida GentaDepartment of Drug Sciences, University of Pavia, V.le Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0001-5710-0588

Funding

Piano Operativo Salute, F13C22001110001 Traiettoria 4 (T4-CN-02) - Interventi per la creazione di Hub delle Scienze della Vita nei settori della Farmaceutica, del Biomedicale e delle Biotecnologie - Immuno-HUB (Immunoterapia: cura e prevenzione di malatti F13C22001110001Regional Operational Programe of the European Regional Development Fund - POR FESR 2014-2020 program - through the project "DSF (Digital Smart Fluidics): Fluidica Digitale per le Scienze della Vita" 1175234
6 · The paper itself

Abstract

Lipid-based nanocarriers have emerged as helpful tools to deliver sensible biomolecules such as proteins and oligonucleotides. To have a fast and robust microfluidic-based nanoparticle synthesis method, the setup of versatile equipment should allow for the rapid transfer to scale cost-effectively while ensuring tunable, precise and reproducible nanoparticle attributes. The present work aims to assess the effect of different micromixer geometries on the manufacturing of lipid nanocarriers taking into account the influence on the mixing efficiency by changing the fluid-fluid interface and indeed the mass transfer. Since the geometry of the adopted micromixer varies from those already published, a Design of Experiment (DoE) was necessary to identify the operating (total flow, flow rate ratio) and formulation (lipid concentration, lipid molar ratios) parameters affecting the nanocarrier quality. The suitable application of the platform was investigated by producing neutral, stealth and cationic liposomes, using DaunoXome

Indexed as

lipid nanocarrierslipid nanoparticlesliposomesmanufacturemicrofluidicsnucleic acidsproteins

Identifiers

PMID38675169
PMCPMC11054535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.